A fully automated one-pot synthesis of [carbonyl- 11C]WAY-100635 for clinical PET applications

A fully automated synthesis of the important 5HT 1A receptor radioligand, [carbonyl- 11C]WAY-100635 ( I), was developed based on the optimized one-pot “wet” synthesis procedure. A modern automated apparatus was constructed from commercially available components and operated via LabView software. In...

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Veröffentlicht in:	Applied radiation and isotopes 2009, Vol.67 (1), p.73-78
Hauptverfasser:	Krasikova, Raisa N., Andersson, Jan, Truong, Phong, Nag, Sangram, Shchukin, Evgeny V., Halldin, Christer
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT 1A receptors [carbonyl- 11C]WAY-100635 Automated synthesis Carbon Radioisotopes Humans Medicin och hälsovetenskap Piperazines - chemical synthesis Positron emission tomography Pyridines - chemical synthesis Radiopharmaceuticals - chemical synthesis Receptors, Serotonin, 5-HT1 Serotonin Antagonists - chemical synthesis
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Beschreibung
Zusammenfassung:	A fully automated synthesis of the important 5HT 1A receptor radioligand, [carbonyl- 11C]WAY-100635 ( I), was developed based on the optimized one-pot “wet” synthesis procedure. A modern automated apparatus was constructed from commercially available components and operated via LabView software. In average, (906±525) MBq ( n=94) of ( I) was obtained from 40 min bombardment at 50 μA beam current within 50 min synthesis time. The specific radioactivity (SA) at the time of injection was (50.5±29.3) GBq/μmol ( n=94).
ISSN:	0969-8043 1872-9800 1872-9800
DOI:	10.1016/j.apradiso.2008.07.008