Genetic variants of TNFSF4 and risk for carotid artery disease and stroke

In two independent human cohorts, the minor allele of SNP rs3850641 in TNFSF4 was significantly more frequent in individuals with myocardial infarction than in controls. In mice, Tnfsf4 expression is associated with increased atherosclerosis. The expression of TNFSF4 in human atherosclerosis and the...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2009-04, Vol.87 (4), p.337-346
Hauptverfasser:	Olofsson, P. S., Söderström, L. Å., Jern, C., Sirsjö, A., Ria, M., Sundler, E., de Faire, U., Wiklund, P. G., Öhrvik, J., Hedin, U., Paulsson-Berne, G., Hamsten, A., Eriksson, P., Hansson, G. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Biological and medical sciences Biomedical and Life Sciences Biomedicine Carotid Artery Diseases - genetics Carotid Artery Diseases - metabolism Carotid Artery Diseases - pathology Cells, Cultured Cerebrovascular disease Cohort Studies Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Female Fluorescent Antibody Technique Gene expression Gene Frequency General aspects Genetic Predisposition to Disease Genetic Variation Genotype Human Genetics Humans Inflammation Internal Medicine Male MEDICAL AND HEALTH SCIENCES Medical sciences MEDICIN MEDICIN OCH HÄLSOVETENSKAP MEDICINE Middle Aged Molecular Medicine Neurology Original Article OX40 Ligand - genetics OX40 Ligand - metabolism Polymorphism, Single Nucleotide Reverse Transcriptase Polymerase Chain Reaction Risk Factors RNA, Messenger - genetics RNA, Messenger - metabolism Single nucleotide polymorphism Stroke - genetics Stroke - metabolism Stroke - pathology Tumor Necrosis Factor-alpha - pharmacology Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:	In two independent human cohorts, the minor allele of SNP rs3850641 in TNFSF4 was significantly more frequent in individuals with myocardial infarction than in controls. In mice, Tnfsf4 expression is associated with increased atherosclerosis. The expression of TNFSF4 in human atherosclerosis and the association between genotype and cerebrovascular disease have not yet been investigated. TNFSF4 messenger RNA (mRNA) levels were significantly higher in human atherosclerotic lesions compared with controls (730 ± 30 vs 330 ± 65 arbitrary units, p
ISSN:	0946-2716 1432-1440 1432-1440
DOI:	10.1007/s00109-008-0412-5