Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome
Primary Sjögren's syndrome (SS) shares many features with systemic lupus erythematosus (SLE). Here we investigated the association of the three major polymorphisms in IRF5 and STAT4 found to be associated with SLE, in patients from Sweden and Norway with primary SS. These polymorphisms are a 5-...
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| Veröffentlicht in: | Genes and immunity 2009-01, Vol.10 (1), p.68-76 |
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| creator | Nordmark, G Kristjansdottir, G Theander, E Eriksson, P Brun, J G Wang, C Padyukov, L Truedsson, L Alm, G Eloranta, M-L Jonsson, R Rönnblom, L Syvänen, A-C |
| description | Primary Sjögren's syndrome (SS) shares many features with systemic lupus erythematosus (SLE). Here we investigated the association of the three major polymorphisms in
IRF5
and
STAT4
found to be associated with SLE, in patients from Sweden and Norway with primary SS. These polymorphisms are a 5-bp CGGGG indel in the promoter of
IRF5
, the single nucleotide polymorphism (SNP) rs10488631 downstream of
IRF5
and the
STAT4
SNP rs7582694, which tags the major risk haplotype of STAT4. We observed strong signals for association between all three polymorphisms and primary SS, with odds ratios (ORs) >1.4 and
P
-values |
| doi_str_mv | 10.1038/gene.2008.94 |
| format | Article |
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IRF5
and
STAT4
found to be associated with SLE, in patients from Sweden and Norway with primary SS. These polymorphisms are a 5-bp CGGGG indel in the promoter of
IRF5
, the single nucleotide polymorphism (SNP) rs10488631 downstream of
IRF5
and the
STAT4
SNP rs7582694, which tags the major risk haplotype of STAT4. We observed strong signals for association between all three polymorphisms and primary SS, with odds ratios (ORs) >1.4 and
P
-values <0.01. We also found a strong additive effect of the three risk alleles of
IRF5
and
STAT4
with an overall significance between the number of risk alleles and primary SS of
P
=2.5 × 10
−9
. The OR for primary SS increased in an additive manner, with an average increase in OR of 1.78. For carriers of two risk alleles, the OR for primary SS is 1.43, whereas carriers of five risk alleles have an OR of 6.78. IRF5 and STAT4 are components of the type I IFN system, and our findings emphasize the importance of this system in the etiopathogenesis of primary SS.</description><identifier>ISSN: 1466-4879</identifier><identifier>ISSN: 1476-5470</identifier><identifier>EISSN: 1476-5470</identifier><identifier>DOI: 10.1038/gene.2008.94</identifier><identifier>PMID: 19092842</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Aged ; Alleles ; Animal and Dairy Science ; Antibodies ; Asian Continental Ancestry Group - genetics ; Asian Continental Ancestry Group - statistics & numerical data ; Basic Medicine ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Case-Control Studies ; Cohort Studies ; Confidence Intervals ; Cytokines ; Dendritic cells ; Diagnosis ; DNA binding proteins ; European Continental Ancestry Group - genetics ; European Continental Ancestry Group - statistics & numerical data ; Female ; Gene Expression ; Gene Frequency ; Genes ; Genetic aspects ; Haplotypes ; Health aspects ; Heterozygote ; Hospitals ; Human Genetics ; Humans ; Husdjursvetenskap ; Immunologi inom det medicinska området ; Immunology ; Immunology in the medical area ; insertion-deletion polymorphism ; Interferon ; Interferon Regulatory Factors - genetics ; Interferon Regulatory Factors - immunology ; IRF5 ; Linear Models ; Linkage Disequilibrium ; Lupus ; Male ; Medical and Health Sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Medicinska och farmaceutiska grundvetenskaper ; Middle Aged ; Norway ; Odds Ratio ; original-article ; Physiological aspects ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; polymorphisms ; primary Sjogren's syndrome ; primary Sjogrens syndrome ; primary Sjögren's syndrome ; Probability ; Rheumatology ; Risk Factors ; single nucleotide ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Sjogren's syndrome ; Sjogren's Syndrome - genetics ; Sjogren's Syndrome - immunology ; STAT4 ; Stat4 protein ; STAT4 Transcription Factor - genetics ; STAT4 Transcription Factor - immunology ; Sweden ; Systemic lupus erythematosus ; Veterinary Science ; Veterinärmedicin</subject><ispartof>Genes and immunity, 2009-01, Vol.10 (1), p.68-76</ispartof><rights>Macmillan Publishers Limited 2009</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2009</rights><rights>Macmillan Publishers Limited 2009.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-92dea615012fc4961e092f116bd0bcfaa014aafd010c1a2db79393a771a0645b3</citedby><cites>FETCH-LOGICAL-c702t-92dea615012fc4961e092f116bd0bcfaa014aafd010c1a2db79393a771a0645b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/gene.2008.94$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/gene.2008.94$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19092842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16624$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103500$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/1312638$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://res.slu.se/id/publ/27845$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:118146010$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Nordmark, G</creatorcontrib><creatorcontrib>Kristjansdottir, G</creatorcontrib><creatorcontrib>Theander, E</creatorcontrib><creatorcontrib>Eriksson, P</creatorcontrib><creatorcontrib>Brun, J G</creatorcontrib><creatorcontrib>Wang, C</creatorcontrib><creatorcontrib>Padyukov, L</creatorcontrib><creatorcontrib>Truedsson, L</creatorcontrib><creatorcontrib>Alm, G</creatorcontrib><creatorcontrib>Eloranta, M-L</creatorcontrib><creatorcontrib>Jonsson, R</creatorcontrib><creatorcontrib>Rönnblom, L</creatorcontrib><creatorcontrib>Syvänen, A-C</creatorcontrib><creatorcontrib>Sveriges lantbruksuniversitet</creatorcontrib><title>Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome</title><title>Genes and immunity</title><addtitle>Genes Immun</addtitle><addtitle>Genes Immun</addtitle><description>Primary Sjögren's syndrome (SS) shares many features with systemic lupus erythematosus (SLE). Here we investigated the association of the three major polymorphisms in
IRF5
and
STAT4
found to be associated with SLE, in patients from Sweden and Norway with primary SS. These polymorphisms are a 5-bp CGGGG indel in the promoter of
IRF5
, the single nucleotide polymorphism (SNP) rs10488631 downstream of
IRF5
and the
STAT4
SNP rs7582694, which tags the major risk haplotype of STAT4. We observed strong signals for association between all three polymorphisms and primary SS, with odds ratios (ORs) >1.4 and
P
-values <0.01. We also found a strong additive effect of the three risk alleles of
IRF5
and
STAT4
with an overall significance between the number of risk alleles and primary SS of
P
=2.5 × 10
−9
. The OR for primary SS increased in an additive manner, with an average increase in OR of 1.78. For carriers of two risk alleles, the OR for primary SS is 1.43, whereas carriers of five risk alleles have an OR of 6.78. IRF5 and STAT4 are components of the type I IFN system, and our findings emphasize the importance of this system in the etiopathogenesis of primary SS.</description><subject>Aged</subject><subject>Alleles</subject><subject>Animal and Dairy Science</subject><subject>Antibodies</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Asian Continental Ancestry Group - statistics & numerical data</subject><subject>Basic Medicine</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Diagnosis</subject><subject>DNA binding proteins</subject><subject>European Continental Ancestry Group - genetics</subject><subject>European Continental Ancestry Group - statistics & numerical data</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Haplotypes</subject><subject>Health aspects</subject><subject>Heterozygote</subject><subject>Hospitals</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Husdjursvetenskap</subject><subject>Immunologi inom det medicinska området</subject><subject>Immunology</subject><subject>Immunology in the medical area</subject><subject>insertion-deletion polymorphism</subject><subject>Interferon</subject><subject>Interferon Regulatory Factors - genetics</subject><subject>Interferon Regulatory Factors - immunology</subject><subject>IRF5</subject><subject>Linear Models</subject><subject>Linkage Disequilibrium</subject><subject>Lupus</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>MEDICIN</subject><subject>Medicin och hälsovetenskap</subject><subject>MEDICINE</subject><subject>Medicinska och farmaceutiska grundvetenskaper</subject><subject>Middle Aged</subject><subject>Norway</subject><subject>Odds Ratio</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>polymorphisms</subject><subject>primary Sjogren's syndrome</subject><subject>primary Sjogrens syndrome</subject><subject>primary Sjögren's syndrome</subject><subject>Probability</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>single nucleotide</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Sjogren's syndrome</subject><subject>Sjogren's Syndrome - genetics</subject><subject>Sjogren's Syndrome - immunology</subject><subject>STAT4</subject><subject>Stat4 protein</subject><subject>STAT4 Transcription Factor - genetics</subject><subject>STAT4 Transcription Factor - immunology</subject><subject>Sweden</subject><subject>Systemic lupus erythematosus</subject><subject>Veterinary Science</subject><subject>Veterinärmedicin</subject><issn>1466-4879</issn><issn>1476-5470</issn><issn>1476-5470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNk9-L1DAQx4so3nn65rMEBUWwa5KmafK4nJ4uHAi3qy8-hDSd1O71x17SqveP-Q_4j5neFteVW5EQMiSf-WZmkomixwTPCE7E6xJamFGMxUyyO9ExYRmPU5bhu6PNecxEJo-iB96vMSaccHk_OiISSyoYPY4-z4ui6quvgMBaML1HnUX9F0CNXncOucpfIl3XUMPNyeLiLEW6LdByNV8xVLVo46pGu2u0XP_8UTpoX3jkr9vCdQ08jO5ZXXt4NK0n0cezt6vT9_H5h3eL0_l5bDJM-1jSAjQnKSbUGiY5gRCcJYTnBc6N1RoTprUtMMGGaFrkmUxkorOMaMxZmicnUbzV9d9gM-RqCkl1ulLT1mWwQKUc84T8m6-HXLtxGR1oJlga-PODfD1swszVlmdMamY5VQkzWDGTSqVNkqhUG8Da4jGtIPfqoNyb6tNcda5Uw6DC66YY_x9eV4HnnLKAP9_iG9ddDeB71VTeQF3rFrrBK85FQlJOA_jsL3DdDa4ND6UoZySjguIx96cHKSKEIEyynVSpa1BVa7veaTPeq-YkfDQpBc8CNbuFCqOApjJdC7YK-3sOL_ccAtPD977Ug_dqsbzYZ6cqGdd578D-rhPBYyWFGvtEjX2ibiJ-MqU15A0UO3hqjD_-SDhqS3C7vG8V_AVOQRpG</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Nordmark, G</creator><creator>Kristjansdottir, G</creator><creator>Theander, E</creator><creator>Eriksson, P</creator><creator>Brun, J G</creator><creator>Wang, C</creator><creator>Padyukov, L</creator><creator>Truedsson, L</creator><creator>Alm, G</creator><creator>Eloranta, M-L</creator><creator>Jonsson, R</creator><creator>Rönnblom, L</creator><creator>Syvänen, A-C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DG8</scope><scope>DF2</scope><scope>D95</scope></search><sort><creationdate>20090101</creationdate><title>Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome</title><author>Nordmark, G ; Kristjansdottir, G ; Theander, E ; Eriksson, P ; Brun, J G ; Wang, C ; Padyukov, L ; Truedsson, L ; Alm, G ; Eloranta, M-L ; Jonsson, R ; Rönnblom, L ; Syvänen, A-C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-92dea615012fc4961e092f116bd0bcfaa014aafd010c1a2db79393a771a0645b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Animal and Dairy Science</topic><topic>Antibodies</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Asian Continental Ancestry Group - statistics & numerical data</topic><topic>Basic Medicine</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Cytokines</topic><topic>Dendritic cells</topic><topic>Diagnosis</topic><topic>DNA binding proteins</topic><topic>European Continental Ancestry Group - genetics</topic><topic>European Continental Ancestry Group - statistics & numerical data</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Haplotypes</topic><topic>Health aspects</topic><topic>Heterozygote</topic><topic>Hospitals</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Husdjursvetenskap</topic><topic>Immunologi inom det medicinska området</topic><topic>Immunology</topic><topic>Immunology in the medical area</topic><topic>insertion-deletion polymorphism</topic><topic>Interferon</topic><topic>Interferon Regulatory Factors - genetics</topic><topic>Interferon Regulatory Factors - immunology</topic><topic>IRF5</topic><topic>Linear Models</topic><topic>Linkage Disequilibrium</topic><topic>Lupus</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>MEDICIN</topic><topic>Medicin och hälsovetenskap</topic><topic>MEDICINE</topic><topic>Medicinska och farmaceutiska grundvetenskaper</topic><topic>Middle Aged</topic><topic>Norway</topic><topic>Odds Ratio</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>polymorphisms</topic><topic>primary Sjogren's syndrome</topic><topic>primary Sjogrens syndrome</topic><topic>primary Sjögren's syndrome</topic><topic>Probability</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>single nucleotide</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Sjogren's syndrome</topic><topic>Sjogren's Syndrome - genetics</topic><topic>Sjogren's Syndrome - immunology</topic><topic>STAT4</topic><topic>Stat4 protein</topic><topic>STAT4 Transcription Factor - genetics</topic><topic>STAT4 Transcription Factor - immunology</topic><topic>Sweden</topic><topic>Systemic lupus erythematosus</topic><topic>Veterinary Science</topic><topic>Veterinärmedicin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nordmark, G</creatorcontrib><creatorcontrib>Kristjansdottir, G</creatorcontrib><creatorcontrib>Theander, E</creatorcontrib><creatorcontrib>Eriksson, P</creatorcontrib><creatorcontrib>Brun, J G</creatorcontrib><creatorcontrib>Wang, C</creatorcontrib><creatorcontrib>Padyukov, L</creatorcontrib><creatorcontrib>Truedsson, L</creatorcontrib><creatorcontrib>Alm, G</creatorcontrib><creatorcontrib>Eloranta, M-L</creatorcontrib><creatorcontrib>Jonsson, R</creatorcontrib><creatorcontrib>Rönnblom, L</creatorcontrib><creatorcontrib>Syvänen, A-C</creatorcontrib><creatorcontrib>Sveriges lantbruksuniversitet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Linköpings universitet</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Lunds universitet</collection><jtitle>Genes and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nordmark, G</au><au>Kristjansdottir, G</au><au>Theander, E</au><au>Eriksson, P</au><au>Brun, J G</au><au>Wang, C</au><au>Padyukov, L</au><au>Truedsson, L</au><au>Alm, G</au><au>Eloranta, M-L</au><au>Jonsson, R</au><au>Rönnblom, L</au><au>Syvänen, A-C</au><aucorp>Sveriges lantbruksuniversitet</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome</atitle><jtitle>Genes and immunity</jtitle><stitle>Genes Immun</stitle><addtitle>Genes Immun</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>10</volume><issue>1</issue><spage>68</spage><epage>76</epage><pages>68-76</pages><issn>1466-4879</issn><issn>1476-5470</issn><eissn>1476-5470</eissn><abstract>Primary Sjögren's syndrome (SS) shares many features with systemic lupus erythematosus (SLE). Here we investigated the association of the three major polymorphisms in
IRF5
and
STAT4
found to be associated with SLE, in patients from Sweden and Norway with primary SS. These polymorphisms are a 5-bp CGGGG indel in the promoter of
IRF5
, the single nucleotide polymorphism (SNP) rs10488631 downstream of
IRF5
and the
STAT4
SNP rs7582694, which tags the major risk haplotype of STAT4. We observed strong signals for association between all three polymorphisms and primary SS, with odds ratios (ORs) >1.4 and
P
-values <0.01. We also found a strong additive effect of the three risk alleles of
IRF5
and
STAT4
with an overall significance between the number of risk alleles and primary SS of
P
=2.5 × 10
−9
. The OR for primary SS increased in an additive manner, with an average increase in OR of 1.78. For carriers of two risk alleles, the OR for primary SS is 1.43, whereas carriers of five risk alleles have an OR of 6.78. IRF5 and STAT4 are components of the type I IFN system, and our findings emphasize the importance of this system in the etiopathogenesis of primary SS.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19092842</pmid><doi>10.1038/gene.2008.94</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1466-4879 |
| ispartof | Genes and immunity, 2009-01, Vol.10 (1), p.68-76 |
| issn | 1466-4879 1476-5470 1476-5470 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_560631 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Aged Alleles Animal and Dairy Science Antibodies Asian Continental Ancestry Group - genetics Asian Continental Ancestry Group - statistics & numerical data Basic Medicine Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Cohort Studies Confidence Intervals Cytokines Dendritic cells Diagnosis DNA binding proteins European Continental Ancestry Group - genetics European Continental Ancestry Group - statistics & numerical data Female Gene Expression Gene Frequency Genes Genetic aspects Haplotypes Health aspects Heterozygote Hospitals Human Genetics Humans Husdjursvetenskap Immunologi inom det medicinska området Immunology Immunology in the medical area insertion-deletion polymorphism Interferon Interferon Regulatory Factors - genetics Interferon Regulatory Factors - immunology IRF5 Linear Models Linkage Disequilibrium Lupus Male Medical and Health Sciences MEDICIN Medicin och hälsovetenskap MEDICINE Medicinska och farmaceutiska grundvetenskaper Middle Aged Norway Odds Ratio original-article Physiological aspects Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide polymorphisms primary Sjogren's syndrome primary Sjogrens syndrome primary Sjögren's syndrome Probability Rheumatology Risk Factors single nucleotide Single nucleotide polymorphisms Single-nucleotide polymorphism Sjogren's syndrome Sjogren's Syndrome - genetics Sjogren's Syndrome - immunology STAT4 Stat4 protein STAT4 Transcription Factor - genetics STAT4 Transcription Factor - immunology Sweden Systemic lupus erythematosus Veterinary Science Veterinärmedicin |
| title | Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T15%3A24%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Additive%20effects%20of%20the%20major%20risk%20alleles%20of%20IRF5%20and%20STAT4%20in%20primary%20Sj%C3%B6gren's%20syndrome&rft.jtitle=Genes%20and%20immunity&rft.au=Nordmark,%20G&rft.aucorp=Sveriges%20lantbruksuniversitet&rft.date=2009-01-01&rft.volume=10&rft.issue=1&rft.spage=68&rft.epage=76&rft.pages=68-76&rft.issn=1466-4879&rft.eissn=1476-5470&rft_id=info:doi/10.1038/gene.2008.94&rft_dat=%3Cgale_swepu%3EA192899867%3C/gale_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=218881494&rft_id=info:pmid/19092842&rft_galeid=A192899867&rfr_iscdi=true |