Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome

Primary Sjögren's syndrome (SS) shares many features with systemic lupus erythematosus (SLE). Here we investigated the association of the three major polymorphisms in IRF5 and STAT4 found to be associated with SLE, in patients from Sweden and Norway with primary SS. These polymorphisms are a 5-...

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Veröffentlicht in:	Genes and immunity 2009-01, Vol.10 (1), p.68-76
Hauptverfasser:	Nordmark, G, Kristjansdottir, G, Theander, E, Eriksson, P, Brun, J G, Wang, C, Padyukov, L, Truedsson, L, Alm, G, Eloranta, M-L, Jonsson, R, Rönnblom, L, Syvänen, A-C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Animal and Dairy Science Antibodies Asian Continental Ancestry Group - genetics Asian Continental Ancestry Group - statistics & numerical data Basic Medicine Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Cohort Studies Confidence Intervals Cytokines Dendritic cells Diagnosis DNA binding proteins European Continental Ancestry Group - genetics European Continental Ancestry Group - statistics & numerical data Female Gene Expression Gene Frequency Genes Genetic aspects Haplotypes Health aspects Heterozygote Hospitals Human Genetics Humans Husdjursvetenskap Immunologi inom det medicinska området Immunology Immunology in the medical area insertion-deletion polymorphism Interferon Interferon Regulatory Factors - genetics Interferon Regulatory Factors - immunology IRF5 Linear Models Linkage Disequilibrium Lupus Male Medical and Health Sciences MEDICIN Medicin och hälsovetenskap MEDICINE Medicinska och farmaceutiska grundvetenskaper Middle Aged Norway Odds Ratio original-article Physiological aspects Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide polymorphisms primary Sjogren's syndrome primary Sjogrens syndrome primary Sjögren's syndrome Probability Rheumatology Risk Factors single nucleotide Single nucleotide polymorphisms Single-nucleotide polymorphism Sjogren's syndrome Sjogren's Syndrome - genetics Sjogren's Syndrome - immunology STAT4 Stat4 protein STAT4 Transcription Factor - genetics STAT4 Transcription Factor - immunology Sweden Systemic lupus erythematosus Veterinary Science Veterinärmedicin
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Zusammenfassung:	Primary Sjögren's syndrome (SS) shares many features with systemic lupus erythematosus (SLE). Here we investigated the association of the three major polymorphisms in IRF5 and STAT4 found to be associated with SLE, in patients from Sweden and Norway with primary SS. These polymorphisms are a 5-bp CGGGG indel in the promoter of IRF5 , the single nucleotide polymorphism (SNP) rs10488631 downstream of IRF5 and the STAT4 SNP rs7582694, which tags the major risk haplotype of STAT4. We observed strong signals for association between all three polymorphisms and primary SS, with odds ratios (ORs) >1.4 and P -values
ISSN:	1466-4879 1476-5470 1476-5470
DOI:	10.1038/gene.2008.94