Hedgehog in Wnterland

Hedgehog in Wnterland

Hedgehog signaling has a key role in hair follicle development, as well as in induction of the most common cancer in individuals of European descent, basal cell carcinoma (BCC). A new study shows that BCCs strongly resemble embryonic hair follicles and that BCC induction requires active Wnt/β-cateni...

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Veröffentlicht in:Nature genetics 2008-09, Vol.40 (9), p.1040-1041
Hauptverfasser: Roop, Dennis, Toftgård, Rune
Format: Artikel
Sprache:eng
Schlagworte:
Agriculture
Animal Genetics and Genomics
Basal cell carcinoma
beta Catenin - metabolism
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Carcinoma, Basal Cell - genetics
Care and treatment
Cellular signal transduction
Gene expression
Gene Function
Genetic aspects
Hair
Hair Follicle - embryology
Hedgehog Proteins - genetics
Human Genetics
Humans
Medicin och hälsovetenskap
news-and-views
Proteins
Risk factors
Signal Transduction
Skin Neoplasms - genetics
Stem cells
Tumors
Wnt Proteins - metabolism
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Beschreibung
Zusammenfassung:Hedgehog signaling has a key role in hair follicle development, as well as in induction of the most common cancer in individuals of European descent, basal cell carcinoma (BCC). A new study shows that BCCs strongly resemble embryonic hair follicles and that BCC induction requires active Wnt/β-catenin signaling.
ISSN:1061-4036
1546-1718
DOI:10.1038/ng0908-1040