Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager and colleagues with the Cancer Genetics Markers of Susceptibility (CGEMS) initiative report a new association to prostate cancer at chromosome 8q24. This defines a new locus, region 4, which shows association to prostate cancer susceptibility independent of previously reported associ...

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Veröffentlicht in:	Nature genetics 2009-10, Vol.41 (10), p.1055-1057
Hauptverfasser:	Yeager, Meredith, Chatterjee, Nilanjan, Ciampa, Julia, Jacobs, Kevin B, Gonzalez-Bosquet, Jesus, Hayes, Richard B, Kraft, Peter, Wacholder, Sholom, Orr, Nick, Berndt, Sonja, Yu, Kai, Hutchinson, Amy, Wang, Zhaoming, Amundadottir, Laufey, Feigelson, Heather Spencer, Thun, Michael J, Diver, W Ryan, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Schumacher, Fredrick R, Cancel-Tassin, Geraldine, Cussenot, Olivier, Valeri, Antoine, Andriole, Gerald L, Crawford, E David, Haiman, Christopher A, Henderson, Brian, Kolonel, Laurence, Le Marchand, Loic, Siddiq, Afshan, Riboli, Elio, Key, Timothy J, Kaaks, Rudolf, Isaacs, William, Isaacs, Sarah, Wiley, Kathleen E, Gronberg, Henrik, Wiklund, Fredrik, Stattin, Pär, Xu, Jianfeng, Zheng, S Lilly, Sun, Jielin, Vatten, Lars J, Hveem, Kristian, Kumle, Merethe, Tucker, Margaret, Gerhard, Daniela S, Hoover, Robert N, Fraumeni, Joseph F, Hunter, David J, Thomas, Gilles, Chanock, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast cancer brief-communication Cancer Research Chromosomes, Human, Pair 8 Classical genetics, quantitative genetics, hybrids Disease Susceptibility Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Genome, Human Genome-Wide Association Study Genotype Gynecology. Andrology. Obstetrics Health aspects Health risks Human Genetics Humans Larynx Male Male genital diseases Medical sciences Methods, theories and miscellaneous Nephrology. Urinary tract diseases Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - genetics Risk Factors Single nucleotide polymorphisms Studies Tumors Tumors of the urinary system Urinary tract. Prostate gland White People - genetics
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Zusammenfassung:	Meredith Yeager and colleagues with the Cancer Genetics Markers of Susceptibility (CGEMS) initiative report a new association to prostate cancer at chromosome 8q24. This defines a new locus, region 4, which shows association to prostate cancer susceptibility independent of previously reported associations at 8q24. We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10 −10 , heterozygote OR = 1.17, 95% CI 1.10–1.24; homozygote OR = 1.33, 95% CI 1.21–1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.
ISSN:	1061-4036 1546-1718 1546-1718
DOI:	10.1038/ng.444