Topical chemotherapy for ocular surface squamous neoplasia: current status

Although there are no randomised trials directly comparing topical chemotherapeutic agents mitomycin-C, 5-fluorouracil, and interferon-α2b, published studies indicate equal efficacy of these agents for treatment of non-invasive ocular surface squamous neoplasia (80%–88%). 5-Fluorouracil may be prefe...

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Veröffentlicht in:	British journal of ophthalmology 2010-05, Vol.94 (5), p.532-535
Hauptverfasser:	Sepulveda, Ricardo, Pe'er, Jacob, Midena, Edoardo, Seregard, Stefan, Dua, Harminder S, Singh, Arun D
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Antibiotics, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - administration & dosage Antineoplastic Agents - administration & dosage Biological and medical sciences Cell adhesion & migration Cell cycle Chemotherapy Eye Neoplasms - drug therapy Fibroblasts Fluorouracil - administration & dosage Humans Interferon Interferon-alpha - administration & dosage Medical sciences Miscellaneous Mitomycin - administration & dosage Molecular weight Neoplasms, Squamous Cell - drug therapy Ocular surface Ophthalmology Patients Recombinant Proteins Stem cells Surgery
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Beschreibung
Zusammenfassung:	Although there are no randomised trials directly comparing topical chemotherapeutic agents mitomycin-C, 5-fluorouracil, and interferon-α2b, published studies indicate equal efficacy of these agents for treatment of non-invasive ocular surface squamous neoplasia (80%–88%). 5-Fluorouracil may be preferred, given low incidence of serious side effects and low cost to the patient.
ISSN:	0007-1161 1468-2079
DOI:	10.1136/bjo.2009.160820