Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey
Background End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design Cross-sectional survey. Setting & Participants Total populations aged 20-60 yea...
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creator | Torres, Cecilia, MD Aragón, Aurora, PhD González, Marvin, MSc López, Indiana, PhD Jakobsson, Kristina, PhD Elinder, Carl-Gustaf, PhD Lundberg, Ingvar, PhD Wesseling, Catharina, PhD |
description | Background End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design Cross-sectional survey. Setting & Participants Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate 300 mg/dL) range. Results Prevalences of abnormal SCr levels: 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate |
doi_str_mv | 10.1053/j.ajkd.2009.12.012 |
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We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design Cross-sectional survey. Setting & Participants Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate <60 mL/min/1.73 m2 , proteinuria stratified in the low (dipstick protein excretion, 30-300 mg/dL) and high (>300 mg/dL) range. Results Prevalences of abnormal SCr levels: 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate <60 mL/min/1.73 m2 : 14% (of all men) and 3% (of all women); in the listed villages, 19% and 5%, 17% and 4%, 10% and 2%, 0% and 0%, and 7% and 0%, respectively. Proteinuria, predominantly in the low range, affected 14% and 11% of all men and women without marked differences between villages. By occupation, abnormal SCr levels occurred in 31% and 24% of male and female agricultural workers at 100-300 m above sea level, but not at higher altitudes, and also was high in male artisans (43%), construction workers (15%), and miners (14%). In logistic regression models, for the banana/sugarcane and mining/subsistence farming villages, high blood pressure and age were significant predictors of abnormal SCr levels in men, and for mining/subsistence farming, age in women. Limitations Causality is not addressed. Conclusions In some Nicaraguan villages and population segments, men in particular show a high prevalence of decreased kidney function of unknown origin, possibly environmental or occupational.</description><identifier>ISSN: 0272-6386</identifier><identifier>ISSN: 1523-6838</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1053/j.ajkd.2009.12.012</identifier><identifier>PMID: 20116154</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; agriculture ; Biological and medical sciences ; Central America ; chronic kidney disease (CKD) ; Clinical Medicine ; Cross-Sectional Studies ; Female ; glomerular filtration ; glomerular filtration rate (GFR) ; Health Surveys ; Humans ; Kidney - physiopathology ; Kidney Diseases - epidemiology ; Kidney Diseases - physiopathology ; Kidneys ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Middle Aged ; Nephrology ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nicaragua ; occupation ; Prevalence ; rate (GFR) ; Renal failure ; Serum creatinine ; Urinary system involvement in other diseases. Miscellaneous ; Urologi och njurmedicin ; Urology and Nephrology ; Young Adult</subject><ispartof>American journal of kidney diseases, 2010-03, Vol.55 (3), p.485-496</ispartof><rights>National Kidney Foundation, Inc.</rights><rights>2010 National Kidney Foundation, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c650t-71da610e24f36a2a3bf8caa97083dec171b2fd473c2677cce0b6e365ea5daf413</citedby><cites>FETCH-LOGICAL-c650t-71da610e24f36a2a3bf8caa97083dec171b2fd473c2677cce0b6e365ea5daf413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S027263860901587X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22483352$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20116154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-136702$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/1589817$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:120100349$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Torres, Cecilia, MD</creatorcontrib><creatorcontrib>Aragón, Aurora, PhD</creatorcontrib><creatorcontrib>González, Marvin, MSc</creatorcontrib><creatorcontrib>López, Indiana, PhD</creatorcontrib><creatorcontrib>Jakobsson, Kristina, PhD</creatorcontrib><creatorcontrib>Elinder, Carl-Gustaf, PhD</creatorcontrib><creatorcontrib>Lundberg, Ingvar, PhD</creatorcontrib><creatorcontrib>Wesseling, Catharina, PhD</creatorcontrib><title>Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>Background End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design Cross-sectional survey. Setting & Participants Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate <60 mL/min/1.73 m2 , proteinuria stratified in the low (dipstick protein excretion, 30-300 mg/dL) and high (>300 mg/dL) range. Results Prevalences of abnormal SCr levels: 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate <60 mL/min/1.73 m2 : 14% (of all men) and 3% (of all women); in the listed villages, 19% and 5%, 17% and 4%, 10% and 2%, 0% and 0%, and 7% and 0%, respectively. Proteinuria, predominantly in the low range, affected 14% and 11% of all men and women without marked differences between villages. By occupation, abnormal SCr levels occurred in 31% and 24% of male and female agricultural workers at 100-300 m above sea level, but not at higher altitudes, and also was high in male artisans (43%), construction workers (15%), and miners (14%). In logistic regression models, for the banana/sugarcane and mining/subsistence farming villages, high blood pressure and age were significant predictors of abnormal SCr levels in men, and for mining/subsistence farming, age in women. Limitations Causality is not addressed. Conclusions In some Nicaraguan villages and population segments, men in particular show a high prevalence of decreased kidney function of unknown origin, possibly environmental or occupational.</description><subject>Adult</subject><subject>agriculture</subject><subject>Biological and medical sciences</subject><subject>Central America</subject><subject>chronic kidney disease (CKD)</subject><subject>Clinical Medicine</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>glomerular filtration</subject><subject>glomerular filtration rate (GFR)</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Kidney Diseases - epidemiology</subject><subject>Kidney Diseases - physiopathology</subject><subject>Kidneys</subject><subject>Klinisk medicin</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medical sciences</subject><subject>MEDICIN</subject><subject>Medicin och hälsovetenskap</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Nicaragua</subject><subject>occupation</subject><subject>Prevalence</subject><subject>rate (GFR)</subject><subject>Renal failure</subject><subject>Serum creatinine</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urologi och njurmedicin</subject><subject>Urology and Nephrology</subject><subject>Young Adult</subject><issn>0272-6386</issn><issn>1523-6838</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl9rFDEUxQdR7Fr9Aj7IvIgvzpo_k0xWirBurYpFkVrx7ZLJ3CnZnU3WZNOy396Mu1YQ6sMl4fI7hwvnFMVTSqaUCP5qOdXLVTdlhMymlE0JZfeKCRWMV1Jxdb-YENawSnIlj4pHMS5JBrmUD4sjRiiVVNST4uspmoA6Yld-sp3DXXmWnNla70rfl5du5fyNKxc6RSytKz9bo4O-Svp1OS8Xfr1Ozm531dvfBhcpXOPucfGg10PEJ4f3uLg8e_dt8aE6__L-42J-XhkpyLZqaKclJcjqnkvNNG97ZbSeNUTxDg1taMv6rm64YbJpjEHSSuRSoBad7mvKj4tq7xtvcJNa2AS71mEHXls4rFb5hyAEr2uR-fM7-SFt8rR5RoFSPUfFNEilJdS0VtASpQA1IaoXVM86nu1e3ml3ar_PwYcrSAkolw1hGX-xxzfB_0wYt7C20eAwaIc-RWg4l0o0aryT7UkTfIwB-1trSmDMHZYw5g5j7kAZ5Nyz6NnBPrVr7G4lf4LOwPMDoKPRQx-0Mzb-5VitOBej0cmewxzdtcUA0Vh0Bjsb0Gyh8_b_d7z5R24G63JphhXuMC59Ci6XAijELICLsaFjQcmMUKGaH_wXeWzf4g</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Torres, Cecilia, MD</creator><creator>Aragón, Aurora, PhD</creator><creator>González, Marvin, MSc</creator><creator>López, Indiana, PhD</creator><creator>Jakobsson, Kristina, PhD</creator><creator>Elinder, Carl-Gustaf, PhD</creator><creator>Lundberg, Ingvar, PhD</creator><creator>Wesseling, Catharina, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><scope>D95</scope></search><sort><creationdate>20100301</creationdate><title>Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey</title><author>Torres, Cecilia, MD ; Aragón, Aurora, PhD ; González, Marvin, MSc ; López, Indiana, PhD ; Jakobsson, Kristina, PhD ; Elinder, Carl-Gustaf, PhD ; Lundberg, Ingvar, PhD ; Wesseling, Catharina, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c650t-71da610e24f36a2a3bf8caa97083dec171b2fd473c2677cce0b6e365ea5daf413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>agriculture</topic><topic>Biological and medical sciences</topic><topic>Central America</topic><topic>chronic kidney disease (CKD)</topic><topic>Clinical Medicine</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>glomerular filtration</topic><topic>glomerular filtration rate (GFR)</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Kidney Diseases - epidemiology</topic><topic>Kidney Diseases - physiopathology</topic><topic>Kidneys</topic><topic>Klinisk medicin</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medical sciences</topic><topic>MEDICIN</topic><topic>Medicin och hälsovetenskap</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Nicaragua</topic><topic>occupation</topic><topic>Prevalence</topic><topic>rate (GFR)</topic><topic>Renal failure</topic><topic>Serum creatinine</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urologi och njurmedicin</topic><topic>Urology and Nephrology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torres, Cecilia, MD</creatorcontrib><creatorcontrib>Aragón, Aurora, PhD</creatorcontrib><creatorcontrib>González, Marvin, MSc</creatorcontrib><creatorcontrib>López, Indiana, PhD</creatorcontrib><creatorcontrib>Jakobsson, Kristina, PhD</creatorcontrib><creatorcontrib>Elinder, Carl-Gustaf, PhD</creatorcontrib><creatorcontrib>Lundberg, Ingvar, PhD</creatorcontrib><creatorcontrib>Wesseling, Catharina, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Lunds universitet</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torres, Cecilia, MD</au><au>Aragón, Aurora, PhD</au><au>González, Marvin, MSc</au><au>López, Indiana, PhD</au><au>Jakobsson, Kristina, PhD</au><au>Elinder, Carl-Gustaf, PhD</au><au>Lundberg, Ingvar, PhD</au><au>Wesseling, Catharina, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>55</volume><issue>3</issue><spage>485</spage><epage>496</epage><pages>485-496</pages><issn>0272-6386</issn><issn>1523-6838</issn><eissn>1523-6838</eissn><abstract>Background End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design Cross-sectional survey. Setting & Participants Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate <60 mL/min/1.73 m2 , proteinuria stratified in the low (dipstick protein excretion, 30-300 mg/dL) and high (>300 mg/dL) range. Results Prevalences of abnormal SCr levels: 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate <60 mL/min/1.73 m2 : 14% (of all men) and 3% (of all women); in the listed villages, 19% and 5%, 17% and 4%, 10% and 2%, 0% and 0%, and 7% and 0%, respectively. Proteinuria, predominantly in the low range, affected 14% and 11% of all men and women without marked differences between villages. By occupation, abnormal SCr levels occurred in 31% and 24% of male and female agricultural workers at 100-300 m above sea level, but not at higher altitudes, and also was high in male artisans (43%), construction workers (15%), and miners (14%). In logistic regression models, for the banana/sugarcane and mining/subsistence farming villages, high blood pressure and age were significant predictors of abnormal SCr levels in men, and for mining/subsistence farming, age in women. Limitations Causality is not addressed. Conclusions In some Nicaraguan villages and population segments, men in particular show a high prevalence of decreased kidney function of unknown origin, possibly environmental or occupational.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20116154</pmid><doi>10.1053/j.ajkd.2009.12.012</doi><tpages>12</tpages></addata></record> |
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subjects | Adult agriculture Biological and medical sciences Central America chronic kidney disease (CKD) Clinical Medicine Cross-Sectional Studies Female glomerular filtration glomerular filtration rate (GFR) Health Surveys Humans Kidney - physiopathology Kidney Diseases - epidemiology Kidney Diseases - physiopathology Kidneys Klinisk medicin Male Medical and Health Sciences Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Middle Aged Nephrology Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nicaragua occupation Prevalence rate (GFR) Renal failure Serum creatinine Urinary system involvement in other diseases. Miscellaneous Urologi och njurmedicin Urology and Nephrology Young Adult |
title | Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey |
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