Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey

Background End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design Cross-sectional survey. Setting & Participants Total populations aged 20-60 yea...

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Veröffentlicht in:American journal of kidney diseases 2010-03, Vol.55 (3), p.485-496
Hauptverfasser: Torres, Cecilia, MD, Aragón, Aurora, PhD, González, Marvin, MSc, López, Indiana, PhD, Jakobsson, Kristina, PhD, Elinder, Carl-Gustaf, PhD, Lundberg, Ingvar, PhD, Wesseling, Catharina, PhD
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container_end_page 496
container_issue 3
container_start_page 485
container_title American journal of kidney diseases
container_volume 55
creator Torres, Cecilia, MD
Aragón, Aurora, PhD
González, Marvin, MSc
López, Indiana, PhD
Jakobsson, Kristina, PhD
Elinder, Carl-Gustaf, PhD
Lundberg, Ingvar, PhD
Wesseling, Catharina, PhD
description Background End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design Cross-sectional survey. Setting & Participants Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate 300 mg/dL) range. Results Prevalences of abnormal SCr levels: 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate
doi_str_mv 10.1053/j.ajkd.2009.12.012
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We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design Cross-sectional survey. Setting &amp; Participants Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate &lt;60 mL/min/1.73 m2 , proteinuria stratified in the low (dipstick protein excretion, 30-300 mg/dL) and high (&gt;300 mg/dL) range. Results Prevalences of abnormal SCr levels: 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate &lt;60 mL/min/1.73 m2 : 14% (of all men) and 3% (of all women); in the listed villages, 19% and 5%, 17% and 4%, 10% and 2%, 0% and 0%, and 7% and 0%, respectively. Proteinuria, predominantly in the low range, affected 14% and 11% of all men and women without marked differences between villages. By occupation, abnormal SCr levels occurred in 31% and 24% of male and female agricultural workers at 100-300 m above sea level, but not at higher altitudes, and also was high in male artisans (43%), construction workers (15%), and miners (14%). In logistic regression models, for the banana/sugarcane and mining/subsistence farming villages, high blood pressure and age were significant predictors of abnormal SCr levels in men, and for mining/subsistence farming, age in women. Limitations Causality is not addressed. Conclusions In some Nicaraguan villages and population segments, men in particular show a high prevalence of decreased kidney function of unknown origin, possibly environmental or occupational.</description><identifier>ISSN: 0272-6386</identifier><identifier>ISSN: 1523-6838</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1053/j.ajkd.2009.12.012</identifier><identifier>PMID: 20116154</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; agriculture ; Biological and medical sciences ; Central America ; chronic kidney disease (CKD) ; Clinical Medicine ; Cross-Sectional Studies ; Female ; glomerular filtration ; glomerular filtration rate (GFR) ; Health Surveys ; Humans ; Kidney - physiopathology ; Kidney Diseases - epidemiology ; Kidney Diseases - physiopathology ; Kidneys ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Middle Aged ; Nephrology ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nicaragua ; occupation ; Prevalence ; rate (GFR) ; Renal failure ; Serum creatinine ; Urinary system involvement in other diseases. Miscellaneous ; Urologi och njurmedicin ; Urology and Nephrology ; Young Adult</subject><ispartof>American journal of kidney diseases, 2010-03, Vol.55 (3), p.485-496</ispartof><rights>National Kidney Foundation, Inc.</rights><rights>2010 National Kidney Foundation, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c650t-71da610e24f36a2a3bf8caa97083dec171b2fd473c2677cce0b6e365ea5daf413</citedby><cites>FETCH-LOGICAL-c650t-71da610e24f36a2a3bf8caa97083dec171b2fd473c2677cce0b6e365ea5daf413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S027263860901587X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=22483352$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20116154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-136702$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/1589817$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:120100349$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Torres, Cecilia, MD</creatorcontrib><creatorcontrib>Aragón, Aurora, PhD</creatorcontrib><creatorcontrib>González, Marvin, MSc</creatorcontrib><creatorcontrib>López, Indiana, PhD</creatorcontrib><creatorcontrib>Jakobsson, Kristina, PhD</creatorcontrib><creatorcontrib>Elinder, Carl-Gustaf, PhD</creatorcontrib><creatorcontrib>Lundberg, Ingvar, PhD</creatorcontrib><creatorcontrib>Wesseling, Catharina, PhD</creatorcontrib><title>Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>Background End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design Cross-sectional survey. Setting &amp; Participants Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate &lt;60 mL/min/1.73 m2 , proteinuria stratified in the low (dipstick protein excretion, 30-300 mg/dL) and high (&gt;300 mg/dL) range. Results Prevalences of abnormal SCr levels: 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate &lt;60 mL/min/1.73 m2 : 14% (of all men) and 3% (of all women); in the listed villages, 19% and 5%, 17% and 4%, 10% and 2%, 0% and 0%, and 7% and 0%, respectively. Proteinuria, predominantly in the low range, affected 14% and 11% of all men and women without marked differences between villages. By occupation, abnormal SCr levels occurred in 31% and 24% of male and female agricultural workers at 100-300 m above sea level, but not at higher altitudes, and also was high in male artisans (43%), construction workers (15%), and miners (14%). In logistic regression models, for the banana/sugarcane and mining/subsistence farming villages, high blood pressure and age were significant predictors of abnormal SCr levels in men, and for mining/subsistence farming, age in women. Limitations Causality is not addressed. Conclusions In some Nicaraguan villages and population segments, men in particular show a high prevalence of decreased kidney function of unknown origin, possibly environmental or occupational.</description><subject>Adult</subject><subject>agriculture</subject><subject>Biological and medical sciences</subject><subject>Central America</subject><subject>chronic kidney disease (CKD)</subject><subject>Clinical Medicine</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>glomerular filtration</subject><subject>glomerular filtration rate (GFR)</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Kidney Diseases - epidemiology</subject><subject>Kidney Diseases - physiopathology</subject><subject>Kidneys</subject><subject>Klinisk medicin</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medical sciences</subject><subject>MEDICIN</subject><subject>Medicin och hälsovetenskap</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Nicaragua</subject><subject>occupation</subject><subject>Prevalence</subject><subject>rate (GFR)</subject><subject>Renal failure</subject><subject>Serum creatinine</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urologi och njurmedicin</subject><subject>Urology and Nephrology</subject><subject>Young Adult</subject><issn>0272-6386</issn><issn>1523-6838</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl9rFDEUxQdR7Fr9Aj7IvIgvzpo_k0xWirBurYpFkVrx7ZLJ3CnZnU3WZNOy396Mu1YQ6sMl4fI7hwvnFMVTSqaUCP5qOdXLVTdlhMymlE0JZfeKCRWMV1Jxdb-YENawSnIlj4pHMS5JBrmUD4sjRiiVVNST4uspmoA6Yld-sp3DXXmWnNla70rfl5du5fyNKxc6RSytKz9bo4O-Svp1OS8Xfr1Ozm531dvfBhcpXOPucfGg10PEJ4f3uLg8e_dt8aE6__L-42J-XhkpyLZqaKclJcjqnkvNNG97ZbSeNUTxDg1taMv6rm64YbJpjEHSSuRSoBad7mvKj4tq7xtvcJNa2AS71mEHXls4rFb5hyAEr2uR-fM7-SFt8rR5RoFSPUfFNEilJdS0VtASpQA1IaoXVM86nu1e3ml3ar_PwYcrSAkolw1hGX-xxzfB_0wYt7C20eAwaIc-RWg4l0o0aryT7UkTfIwB-1trSmDMHZYw5g5j7kAZ5Nyz6NnBPrVr7G4lf4LOwPMDoKPRQx-0Mzb-5VitOBej0cmewxzdtcUA0Vh0Bjsb0Gyh8_b_d7z5R24G63JphhXuMC59Ci6XAijELICLsaFjQcmMUKGaH_wXeWzf4g</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Torres, Cecilia, MD</creator><creator>Aragón, Aurora, PhD</creator><creator>González, Marvin, MSc</creator><creator>López, Indiana, PhD</creator><creator>Jakobsson, Kristina, PhD</creator><creator>Elinder, Carl-Gustaf, PhD</creator><creator>Lundberg, Ingvar, PhD</creator><creator>Wesseling, Catharina, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><scope>D95</scope></search><sort><creationdate>20100301</creationdate><title>Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey</title><author>Torres, Cecilia, MD ; Aragón, Aurora, PhD ; González, Marvin, MSc ; López, Indiana, PhD ; Jakobsson, Kristina, PhD ; Elinder, Carl-Gustaf, PhD ; Lundberg, Ingvar, PhD ; Wesseling, Catharina, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c650t-71da610e24f36a2a3bf8caa97083dec171b2fd473c2677cce0b6e365ea5daf413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>agriculture</topic><topic>Biological and medical sciences</topic><topic>Central America</topic><topic>chronic kidney disease (CKD)</topic><topic>Clinical Medicine</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>glomerular filtration</topic><topic>glomerular filtration rate (GFR)</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Kidney Diseases - epidemiology</topic><topic>Kidney Diseases - physiopathology</topic><topic>Kidneys</topic><topic>Klinisk medicin</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medical sciences</topic><topic>MEDICIN</topic><topic>Medicin och hälsovetenskap</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Nicaragua</topic><topic>occupation</topic><topic>Prevalence</topic><topic>rate (GFR)</topic><topic>Renal failure</topic><topic>Serum creatinine</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urologi och njurmedicin</topic><topic>Urology and Nephrology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torres, Cecilia, MD</creatorcontrib><creatorcontrib>Aragón, Aurora, PhD</creatorcontrib><creatorcontrib>González, Marvin, MSc</creatorcontrib><creatorcontrib>López, Indiana, PhD</creatorcontrib><creatorcontrib>Jakobsson, Kristina, PhD</creatorcontrib><creatorcontrib>Elinder, Carl-Gustaf, PhD</creatorcontrib><creatorcontrib>Lundberg, Ingvar, PhD</creatorcontrib><creatorcontrib>Wesseling, Catharina, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Lunds universitet</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torres, Cecilia, MD</au><au>Aragón, Aurora, PhD</au><au>González, Marvin, MSc</au><au>López, Indiana, PhD</au><au>Jakobsson, Kristina, PhD</au><au>Elinder, Carl-Gustaf, PhD</au><au>Lundberg, Ingvar, PhD</au><au>Wesseling, Catharina, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>55</volume><issue>3</issue><spage>485</spage><epage>496</epage><pages>485-496</pages><issn>0272-6386</issn><issn>1523-6838</issn><eissn>1523-6838</eissn><abstract>Background End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design Cross-sectional survey. Setting &amp; Participants Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate &lt;60 mL/min/1.73 m2 , proteinuria stratified in the low (dipstick protein excretion, 30-300 mg/dL) and high (&gt;300 mg/dL) range. Results Prevalences of abnormal SCr levels: 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate &lt;60 mL/min/1.73 m2 : 14% (of all men) and 3% (of all women); in the listed villages, 19% and 5%, 17% and 4%, 10% and 2%, 0% and 0%, and 7% and 0%, respectively. Proteinuria, predominantly in the low range, affected 14% and 11% of all men and women without marked differences between villages. By occupation, abnormal SCr levels occurred in 31% and 24% of male and female agricultural workers at 100-300 m above sea level, but not at higher altitudes, and also was high in male artisans (43%), construction workers (15%), and miners (14%). In logistic regression models, for the banana/sugarcane and mining/subsistence farming villages, high blood pressure and age were significant predictors of abnormal SCr levels in men, and for mining/subsistence farming, age in women. Limitations Causality is not addressed. Conclusions In some Nicaraguan villages and population segments, men in particular show a high prevalence of decreased kidney function of unknown origin, possibly environmental or occupational.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20116154</pmid><doi>10.1053/j.ajkd.2009.12.012</doi><tpages>12</tpages></addata></record>
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Adult
agriculture
Biological and medical sciences
Central America
chronic kidney disease (CKD)
Clinical Medicine
Cross-Sectional Studies
Female
glomerular filtration
glomerular filtration rate (GFR)
Health Surveys
Humans
Kidney - physiopathology
Kidney Diseases - epidemiology
Kidney Diseases - physiopathology
Kidneys
Klinisk medicin
Male
Medical and Health Sciences
Medical sciences
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Middle Aged
Nephrology
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Nicaragua
occupation
Prevalence
rate (GFR)
Renal failure
Serum creatinine
Urinary system involvement in other diseases. Miscellaneous
Urologi och njurmedicin
Urology and Nephrology
Young Adult
title Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey
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