Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management

Monoclonal gammopathy of undetermined significance (MGUS) was identified in 3.2% of 21 463 residents of Olmsted County, Minnesota, 50 years of age or older. The risk of progression to multiple myeloma, Waldenstrom's macroglobulinemia, AL amyloidosis or a lymphoproliferative disorder is approxim...

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Veröffentlicht in:	LEUKEMIA 2010-06, Vol.24 (6), p.1121-1127
Hauptverfasser:	Kyle, R A, Durie, B G M, Rajkumar, S V, Landgren, O, Blade, J, Merlini, G, Kröger, N, Einsele, H, Vesole, D H, Dimopoulos, M, San Miguel, J, Avet-Loiseau, H, Hajek, R, Chen, W M, Anderson, K C, Ludwig, H, Sonneveld, P, Pavlovsky, S, Palumbo, A, Richardson, P G, Barlogie, B, Greipp, P, Vescio, R, Turesson, I, Westin, J, Boccadoro, M
Format:	Artikel
Sprache:	eng
Schlagworte:	692/499 692/699/1541 692/699/67/1990/804 692/700/1538 Amyloidosis Anemia Asymptomatic Benign monoclonal gammopathy Biological and medical sciences Cancer Cancer and Oncology Cancer och onkologi Cancer Research Care and treatment Clinical Medicine Critical Care Medicine Disease Progression Distribution Electrophoresis Hematologic and hematopoietic diseases Hematology Humans Hypercalcemia Immunodeficiencies. Immunoglobulinopathies Immunoglobulin G Immunoglobulinopathies Immunopathology Intensive Internal Medicine International Myeloma Working Group Klinisk medicin Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes M protein Macroglobulinemia Malignancy Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Medicine Medicine & Public Health MGUS Monoclonal gammopathies monoclonal gammopathy of undetermined significance Monoclonal Gammopathy of Undetermined Significance - complications Monoclonal Gammopathy of Undetermined Significance - diagnosis Monoclonal Gammopathy of Undetermined Significance - therapy Multiple myeloma Multiple Myeloma - diagnosis Multiple Myeloma - etiology Multiple Myeloma - therapy myeloma Oncology Patients Practice guidelines (Medicine) Practice Guidelines as Topic Prognosis Proteins review Risk analysis Risk Factors Serum proteins Smoldering smoldering multiple Waldenstrom's macroglobulinemia White people
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Zusammenfassung:	Monoclonal gammopathy of undetermined significance (MGUS) was identified in 3.2% of 21 463 residents of Olmsted County, Minnesota, 50 years of age or older. The risk of progression to multiple myeloma, Waldenstrom's macroglobulinemia, AL amyloidosis or a lymphoproliferative disorder is approximately 1% per year. Low-risk MGUS is characterized by having an M protein
ISSN:	0887-6924 1476-5551 1476-5551
DOI:	10.1038/leu.2010.60