The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children

Background Although respiratory syncytial virus (RSV) lower respiratory tract infections (LRTIs) in early life are followed by later airway hyperreactivity, it is unclear whether there is a causal relationship between this and an atopic diathesis. Objectives To separate the effects of RSV LRTI and a...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2010-08, Vol.126 (2), p.256-262
Hauptverfasser:	Simões, Eric A.F., MB, BS, DCH, MD, Carbonell-Estrany, Xavier, MD, PhD, Rieger, Christian H.L., MD, Mitchell, Ian, MA, MB, ChB, Fredrick, Linda, MS, Groothuis, Jessie R., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Allergies Allergy and Immunology Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Asthma Asthma - etiology Asthma - prevention & control Child, Preschool Children & youth Disease Susceptibility Family medical history Female Follow-Up Studies Food allergies Food Hypersensitivity - etiology Food Hypersensitivity - prevention & control Humans Infant Infant, Newborn lower respiratory tract infection Male Palivizumab Prospective Studies recurrent wheezing Respiratory Sounds - drug effects Respiratory syncytial virus Respiratory Syncytial Virus Infections - complications Respiratory Syncytial Virus Infections - drug therapy Respiratory Syncytial Viruses Respiratory Tract Infections - complications Respiratory Tract Infections - drug therapy Risk Factors
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Zusammenfassung:	Background Although respiratory syncytial virus (RSV) lower respiratory tract infections (LRTIs) in early life are followed by later airway hyperreactivity, it is unclear whether there is a causal relationship between this and an atopic diathesis. Objectives To separate the effects of RSV LRTI and an atopic diathesis on subsequent recurrent wheezing, we examined the protective effect of previous palivizumab administration against subsequent recurrent wheeze in infants with and without a family history of atopy. Methods A prospective multicenter, matched, double cohort study was conducted in 27 centers in Europe and Canada. The rates of physician-diagnosed recurrent wheezing in premature infants
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2010.05.026