Intra-Arrest Transnasal Evaporative Cooling: A Randomized, Prehospital, Multicenter Study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness)

Transnasal evaporative cooling has sufficient heat transfer capacity for effective intra-arrest cooling and improves survival in swine. The aim of this study was to determine the safety, feasibility, and cooling efficacy of prehospital transnasal cooling in humans and to explore its effects on neuro...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2010-08, Vol.122 (7), p.729-736
Hauptverfasser:	CASTREN, Maaret, NORDBERG, Per, STORM, Christian, PESENTI, Antonio, PACHL, Jan, GUERISSE, Fabien, ELSTE, Thomas, ROESSLER, Markus, FRITZ, Harald, DURNEZ, Pieterjan, BUSCH, Hans-Jörg, INDERBITZEN, Becky, SVENSSON, Leif, BARBUT, Denise, TACCONE, Fabio, VINCENT, Jean-Louise, DESRUELLES, Didier, EICHWEDE, Frank, MOLS, Pierre, SCHWAB, Tilmann, VERGNION, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Aged Biological and medical sciences Blood and lymphatic vessels Body Temperature - physiology Cardiology. Vascular system Cardiovascular system Cold Temperature Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Emergency Medical Services - methods Female Heart Arrest - physiopathology Heart Arrest - therapy Humans Hypothermia, Induced - instrumentation Hypothermia, Induced - methods Male Medical sciences Middle Aged Pharmacology. Drug treatments Prospective Studies Time Factors Vasodilator agents. Cerebral vasodilators
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Zusammenfassung:	Transnasal evaporative cooling has sufficient heat transfer capacity for effective intra-arrest cooling and improves survival in swine. The aim of this study was to determine the safety, feasibility, and cooling efficacy of prehospital transnasal cooling in humans and to explore its effects on neurologically intact survival to hospital discharge. Witnessed cardiac arrest patients with a treatment interval
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.109.931691