Biological, clinical and population relevance of 95 loci for blood lipids

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants...

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Veröffentlicht in:	Nature (London) 2010-08, Vol.466 (7307), p.707-713
Hauptverfasser:	Musunuru, Kiran, Edmondson, Andrew C., Koseki, Masahiro, Pirruccello, James P., Johansen, Christopher T., Barbalic, Maja, Ricketts, Sally L., Bis, Joshua C., Aulchenko, Yurii S., Feitosa, Mary F., Orho-Melander, Marju, Melander, Olle, Li, Xiaohui, Guo, Xiuqing, Shin Cho, Yoon, Jin Go, Min, Jin Kim, Young, Kim, Kyunga, Twee-Hee Ong, Rick, Croteau-Chonka, Damien C., Lange, Leslie A., Song, Kijoung, Hua Zhao, Jing, Yuan, Xin, Zhang, Weihua, Zee, Robert Y. L., Witteman, Jacqueline C. M., Willemsen, Gonneke, Wareham, Nicholas J., Uda, Manuela, Tuomilehto, Jaakko, Tanaka, Toshiko, Surakka, Ida, Spector, Tim D., Soranzo, Nicole, Smit, Johannes H., Sijbrands, Eric J. G., Scuteri, Angelo, Scott, James, Sanna, Serena, Sabatti, Chiara, Ruokonen, Aimo, Rieder, Mark, Psaty, Bruce M., Perola, Markus, Penninx, Brenda W. J. H., Parker, Alex N., Oostra, Ben A., Nieminen, Markku S., McPherson, Ruth, Martin, Nicholas G., Lucas, Gavin, Luben, Robert, Lokki, Marja-Liisa, Lettre, Guillaume, Laaksonen, Reijo, König, Inke R., Jarvelin, Marjo-Riitta, Ingelsson, Erik, Kees Hovingh, G., Heid, Iris M., Hastie, Nicholas D., Gyllensten, Ulf, Groop, Leif C., Gonzalez, Elena, Gieger, Christian, Freimer, Nelson B., Elliott, Paul, Döring, Angela, Demissie, Serkalem, Deloukas, Panagiotis, de Geus, Eco J. C., de Faire, Ulf, Chen, Yii-der I., Caulfield, Mark J., Campbell, Harry, Burtt, Noel P., Bonnycastle, Lori L., Bergman, Richard N., Barroso, Inês, Ballantyne, Christie M., Assimes, Themistocles L., Quertermous, Thomas, Wong, Tien Y., Tai, E-Shyong, Feranil, Alan B., Adair, Linda S., Borecki, Ingrid B., Gabriel, Stacey B., Thorsteinsdottir, Unnur, Munroe, Patricia B., Kooner, Jaspal S., Hegele, Robert A., Boerwinkle, Eric, Strachan, David P., Mooser, Vincent, Reilly, Muredach P., van Duijn, Cornelia M., Peltonen, Leena, Kathiresan, Sekar
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/212 631/208/726/649 631/443/319/2723 692/699/75/593/15 Animals Asian People - genetics Biological and medical sciences Black or African American - genetics Blood lipids Cardiac and Cardiovascular Systems Cardiology. Vascular system Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Clinical Medicine Coronary Artery Disease - blood Coronary Artery Disease - genetics Coronary Artery Disease - therapy Coronary heart disease Endocrinology and Diabetes Endokrinologi och diabetes Europe - ethnology Female Genetic aspects Genetic engineering Genetic Loci - genetics Genetic research Genome-Wide Association Study Genomes Genotype Heart Humanities and Social Sciences Humans Identification and classification Kardiologi Klinisk medicin Lipid Metabolism - genetics Lipids Lipids - blood Lipoproteins Liver - metabolism Male Medical and Health Sciences Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Mice multidisciplinary N-Acetylgalactosaminyltransferases - genetics N-Acetylgalactosaminyltransferases - metabolism Phenotype Plasma Polymorphism, Single Nucleotide - genetics Polypeptide N-acetylgalactosaminyltransferase Properties Protein Phosphatase 1 - genetics Protein Phosphatase 1 - metabolism Reproducibility of Results Risk factors Science Science (multidisciplinary) Triglycerides - blood White People - genetics Women
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Zusammenfassung:	Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci ( P
ISSN:	0028-0836 1476-4687 1476-4687
DOI:	10.1038/nature09270