Transcriptional characteristics of CD4+ T cells in multiple sclerosis: Relative lack of suppressive populations in blood

Background:Multiple sclerosis (MS) is hypothetically caused by autoreactive Th1 and Th17 cells, whereas Th2 and regulatory T cells may confer protection. The development of Th subpopulations is dependant on the expression of lineage-specific transcription factors. Objective:The aim of this study was...

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Veröffentlicht in:	Multiple sclerosis 2011-01, Vol.17 (1), p.57-66
Hauptverfasser:	Edström, M, Mellergård, J, Mjösberg, J, Jenmalm, MC, Vrethem, M, Press, R, Dahle, C, Ernerudh, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Case-Control Studies CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases EBI3 Female Flow Cytometry Forkhead Transcription Factors - genetics FOXP3 GATA3 Transcription Factor - genetics Gene Expression Regulation Humans Immunologi Immunology Interleukins - genetics Male Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Minor Histocompatibility Antigens multiple sclerosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Multiple Sclerosis, Relapsing-Remitting - blood Multiple Sclerosis, Relapsing-Remitting - genetics Multiple Sclerosis, Relapsing-Remitting - immunology Neurology Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - blood RORC T cells T-Box Domain Proteins - genetics transcription factors Transcription Factors - genetics Transcription, Genetic
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Zusammenfassung:	Background:Multiple sclerosis (MS) is hypothetically caused by autoreactive Th1 and Th17 cells, whereas Th2 and regulatory T cells may confer protection. The development of Th subpopulations is dependant on the expression of lineage-specific transcription factors. Objective:The aim of this study was to assess the balance of CD4+T cell populations in relapsing-remitting MS. Methods:Blood mRNA expression of TBX21, GATA3, RORC, FOXP3 and EBI3 was assessed in 33 patients with relapsing-remitting MS and 20 healthy controls. In addition, flow cytometry was performed to assess T lymphocyte numbers. Results:In relapsing-remitting MS, diminished expression of FOXP3 (Treg) was found (p
ISSN:	1352-4585 1477-0970 1477-0970
DOI:	10.1177/1352458510381256