Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials

Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments....

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Veröffentlicht in:	Annals of the rheumatic diseases 2011-03, Vol.70 (3), p.423-427
Hauptverfasser:	van de Sande, Marleen G H, Gerlag, Danielle M, Lodde, Beatrijs M, van Baarsen, Lisa G M, Alivernini, Stefano, Codullo, Veronica, Felea, Ioana, Vieira-Sousa, Elsa, Fearon, Ursula, Reece, Richard, Montecucco, Carlomaurizio, Veale, Douglas J, Pitzalis, Costantino, Emery, Paul, Klareskog, Lars, McInnes, Iain B, Tak, Paul P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antirheumatic Agents - therapeutic use Arthritis Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - pathology Arthroscopy - methods Biological and medical sciences Biomarkers Biopsy Biopsy - methods Biopsy - standards Bones, joints and connective tissue. Antiinflammatory agents Clinical trials Clinical Trials as Topic - standards Disease Diseases of the osteoarticular system Humans Knee Joint - pathology Medical sciences Multicenter Studies as Topic - standards Patients Pharmacology. Drug treatments Synovial Membrane - pathology Synovitis - pathology Treatment Outcome Ultrasonic imaging Ultrasonography, Interventional - methods
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Beschreibung
Zusammenfassung:	Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
ISSN:	0003-4967 1468-2060
DOI:	10.1136/ard.2010.139550