miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer

Colorectal cancer (CRC) is one of the most common and deadly forms of cancer. Despite improved treatment modalities, post-operative recurrence and metastasis remain the major problems for extending patient survival after surgery. This highlights the need to search for biomarkers for prognostication...

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Veröffentlicht in:	International journal of oncology 2011-08, Vol.39 (2), p.311-318
Hauptverfasser:	AKCAKAYA, Pinar, EKELUND, Susanne, KOLOSENKO, Iryna, CARAMUTA, Stefano, ÖZATA, Deniz M, HONG XIE, LINDFORSS, Ulrik, OLIVECRONA, Hans, LUI, Weng-Onn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Cluster Analysis Colorectal Neoplasms - mortality Colorectal Neoplasms - physiopathology Down-Regulation Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Male Medical sciences MicroRNAs - genetics Middle Aged Neoplasm Metastasis Prognosis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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Zusammenfassung:	Colorectal cancer (CRC) is one of the most common and deadly forms of cancer. Despite improved treatment modalities, post-operative recurrence and metastasis remain the major problems for extending patient survival after surgery. This highlights the need to search for biomarkers for prognostication and treatment stratification of colorectal cancer patients. In this study, we applied the SYBR-green quantitative PCR-based array approach to screen for differentially expressed miRNAs between patients with short (
ISSN:	1019-6439 1791-2423
DOI:	10.3892/ijo.2011.1043