Sequence Scrambling in Shotgun Proteomics is Negligible

Analysis of 15,897 low-energy (CAD) and 10,878 higher-energy (HCD) collisional dissociation mass spectra of doubly protonated tryptic peptides taken with high resolution revealed that the rate of sequence scrambling due to b-ion cyclization is negligible (

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Veröffentlicht in:Journal of the American Society for Mass Spectrometry 2011-07, Vol.22 (7), p.1121-1124
Hauptverfasser: Goloborodko, Anton A., Gorshkov, Mikhail V., Good, David M., Zubarev, Roman A.
Format: Artikel
Sprache:eng
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Zusammenfassung:Analysis of 15,897 low-energy (CAD) and 10,878 higher-energy (HCD) collisional dissociation mass spectra of doubly protonated tryptic peptides taken with high resolution revealed that the rate of sequence scrambling due to b-ion cyclization is negligible (
ISSN:1044-0305
1879-1123
1879-1123
DOI:10.1007/s13361-011-0130-z