Influenza A vaccines using linear expression cassettes delivered via electroporation afford full protection against challenge in a mouse model
Highlights ► LECs can induce immune responses which can be enhanced by surface electroporation. ► Levels of immune responses are comparable to responses induced by plasmid. ► Immune responses induced by NP and M2 LECs protect mice from influenza challenge.
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| Veröffentlicht in: | Vaccine 2012-11, Vol.30 (48), p.6946-6954 |
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| container_issue | 48 |
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| container_title | Vaccine |
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| creator | Shen, Xuefei Söderholm, Jonas Lin, Feng Kobinger, Gary Bello, Alexander Gregg, Derek A Broderick, Kate E Sardesai, Niranjan Y |
| description | Highlights ► LECs can induce immune responses which can be enhanced by surface electroporation. ► Levels of immune responses are comparable to responses induced by plasmid. ► Immune responses induced by NP and M2 LECs protect mice from influenza challenge. |
| doi_str_mv | 10.1016/j.vaccine.2012.02.071 |
| format | Article |
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| ispartof | Vaccine, 2012-11, Vol.30 (48), p.6946-6954 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Cutaneous Allergy and Immunology Animal models Animals Antibiotic resistance Antibodies Antibodies, Viral - blood antigens bacterial contamination Contaminants Cytotoxicity Disease Models, Animal DNA vaccines Electrodes Electroporation Electroporation - methods Female genes immune response Immunogenicity Influenza Influenza A Influenza A virus Influenza A virus - genetics Influenza Vaccines - administration & dosage Influenza Vaccines - immunology lethal dose 50 Linear expressing cassettes Lymphocytes T manufacturing Mice Mice, Inbred BALB C Minimally invasive surface electroporation Orthomyxoviridae Orthomyxoviridae Infections - prevention & control pandemic pandemics Plasmids recombinant vaccines Skin Survival Survival Analysis T-Lymphocytes, Cytotoxic - immunology vaccination Vaccine Vaccines, DNA - administration & dosage Vaccines, DNA - immunology viruses |
| title | Influenza A vaccines using linear expression cassettes delivered via electroporation afford full protection against challenge in a mouse model |
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