Influenza A vaccines using linear expression cassettes delivered via electroporation afford full protection against challenge in a mouse model

Highlights ► LECs can induce immune responses which can be enhanced by surface electroporation. ► Levels of immune responses are comparable to responses induced by plasmid. ► Immune responses induced by NP and M2 LECs protect mice from influenza challenge.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2012-11, Vol.30 (48), p.6946-6954
Hauptverfasser:	Shen, Xuefei, Söderholm, Jonas, Lin, Feng, Kobinger, Gary, Bello, Alexander, Gregg, Derek A, Broderick, Kate E, Sardesai, Niranjan Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Allergy and Immunology Animal models Animals Antibiotic resistance Antibodies Antibodies, Viral - blood antigens bacterial contamination Contaminants Cytotoxicity Disease Models, Animal DNA vaccines Electrodes Electroporation Electroporation - methods Female genes immune response Immunogenicity Influenza Influenza A Influenza A virus Influenza A virus - genetics Influenza Vaccines - administration & dosage Influenza Vaccines - immunology lethal dose 50 Linear expressing cassettes Lymphocytes T manufacturing Mice Mice, Inbred BALB C Minimally invasive surface electroporation Orthomyxoviridae Orthomyxoviridae Infections - prevention & control pandemic pandemics Plasmids recombinant vaccines Skin Survival Survival Analysis T-Lymphocytes, Cytotoxic - immunology vaccination Vaccine Vaccines, DNA - administration & dosage Vaccines, DNA - immunology viruses
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Beschreibung
Zusammenfassung:	Highlights ► LECs can induce immune responses which can be enhanced by surface electroporation. ► Levels of immune responses are comparable to responses induced by plasmid. ► Immune responses induced by NP and M2 LECs protect mice from influenza challenge.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.02.071