A genome-wide association study in progressive multiple sclerosis

Background: The role played by genetic factors in influencing the clinical course of multiple sclerosis (MS) is not yet well established. Objective: We aimed to identify genetic variants associated with progressive MS (PrMS). Methods: We conducted a genome-wide association study (GWAS) in 197 patien...

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Veröffentlicht in:	Multiple sclerosis 2012-10, Vol.18 (10), p.1384-1394
Hauptverfasser:	Martinelli-Boneschi, Filippo, Esposito, Federica, Brambilla, Paola, Lindström, Eva, Lavorgna, Giovanni, Stankovich, Jim, Rodegher, Mariaemma, Capra, Ruggero, Ghezzi, Angelo, Coniglio, Gabriella, Colombo, Bruno, Sorosina, Melissa, Martinelli, Vittorio, Booth, David, Oturai, Annette Bang, Stewart, Graeme, Harbo, Hanne F., Kilpatrick, Trevor John, Hillert, Jan, Rubio, Justin P, Abderrahim, Hadi, Wojcik, Jerome, Comi, Giancarlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromosomes, Human, Pair 7 - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Genetic Predisposition to Disease - genetics Genome-Wide Association Study Genotype HLA Antigens - genetics Humans Linkage Disequilibrium Male Medical sciences Medicin och hälsovetenskap Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Multiple Sclerosis, Chronic Progressive - genetics Neurology Polymorphism, Single Nucleotide
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Zusammenfassung:	Background: The role played by genetic factors in influencing the clinical course of multiple sclerosis (MS) is not yet well established. Objective: We aimed to identify genetic variants associated with progressive MS (PrMS). Methods: We conducted a genome-wide association study (GWAS) in 197 patients with PrMS and 234 controls of Italian origin. We tested the top 20 single nucleotide polymorphisms (SNPs) with suggestive evidence of association (p-value
ISSN:	1352-4585 1477-0970 1477-0970
DOI:	10.1177/1352458512439118