Intravenous fluorescein as a cause of immunoglobulin E‐mediated anaphylactic shock

We report a patient with severe anaphylactic shock immediately after injection of i.v. fluorescein. The patient recovered without sequela. Immunoglobulin E (IgE) mechanism was highly suggestive with significant increase in serum tryptase, positive basophil allergen threshold sensitivity (CD‐sens) an...

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Veröffentlicht in:	Acta anaesthesiologica Scandinavica 2012-09, Vol.56 (8), p.1066-1068
Hauptverfasser:	BREIDABLIK, A., PATER, G. H., WALTHER, C., NOPP, A., GUTTORMSEN, A. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Allergens Allergies Anaphylaxis Anaphylaxis - drug therapy Anaphylaxis - etiology Anaphylaxis - immunology Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD - immunology Basophils - immunology Biological and medical sciences Chest Pain - complications Contrast Media - adverse effects Epinephrine - therapeutic use fluorescein Fluorescein - adverse effects Histamine Histamine Release - physiology Humans Immunoglobulin E Immunoglobulin E - immunology Immunoglobulins Intravenous administration Intubation, Intratracheal Leukocytes (basophilic) Male Medical sciences Mucus - physiology Peanuts Skin Tests Tryptase Tryptases Vasoconstrictor Agents - therapeutic use
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Zusammenfassung:	We report a patient with severe anaphylactic shock immediately after injection of i.v. fluorescein. The patient recovered without sequela. Immunoglobulin E (IgE) mechanism was highly suggestive with significant increase in serum tryptase, positive basophil allergen threshold sensitivity (CD‐sens) and histamine release tests towards fluorescein. This is, to our knowledge, the first report where CD‐sens has been used to aid in diagnosing an IgE‐mediated anaphylactic shock caused by fluorescein.
ISSN:	0001-5172 1399-6576
DOI:	10.1111/j.1399-6576.2012.02732.x