Smoothing Out Drug Resistance

Smoothing Out Drug Resistance

Smoothened inhibitors have emerged as successful treatment alternatives for Hedgehog pathway-dependent tumors, but they are linked with the appearance of drug resistance. In this issue of Cancer Cell, Kim and colleagues overcome such resistance by combining approved drugs itraconazole and arsenic tr...

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Veröffentlicht in:Cancer cell 2013-01, Vol.23 (1), p.3-5
Hauptverfasser: Kasper, Maria, Toftgård, Rune
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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Zusammenfassung:Smoothened inhibitors have emerged as successful treatment alternatives for Hedgehog pathway-dependent tumors, but they are linked with the appearance of drug resistance. In this issue of Cancer Cell, Kim and colleagues overcome such resistance by combining approved drugs itraconazole and arsenic trioxide, thus opening a path toward new treatment options.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2012.12.011