A prospective randomized toxicity study to compare reduced‐intensity and myeloablative conditioning in patients with myeloid leukaemia undergoing allogeneic haematopoietic stem cell transplantation

A prospective randomized toxicity study to compare reduced‐intensity and myeloablative conditioning in patients with myeloid leukaemia undergoing allogeneic haematopoietic stem cell transplantation

Background To our knowledge, no randomized toxicity studies have been conducted to compare myeloablative conditioning (MAC) and reduced‐intensity conditioning (RIC) in allogeneic haematopoietic stem cell transplantation (HSCT). Methods Adult patients ≤60 years of age with myeloid leukaemia were rand...

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Veröffentlicht in:Journal of internal medicine 2013-08, Vol.274 (2), p.153-162
Hauptverfasser: Ringdén, O., Erkers, T., Aschan, J., Garming‐Legert, K., Blanc, K., Hägglund, H., Omazic, B., Svenberg, P., Dahllöf, G., Mattsson, J., Ljungman, P., Remberger, M.
Format: Artikel
Sprache:eng
Schlagworte:
acute myeloid leukaemia
Adult
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Busulfan - administration & dosage
Cyclophosphamide - administration & dosage
Cytomegalovirus
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Graft Rejection
Graft Survival
haematopoietic stem cell transplantation
Hematopoietic Stem Cell Transplantation - methods
Humans
Kaplan-Meier Estimate
Leukemia, Myeloid, Acute - mortality
Leukemia, Myeloid, Acute - pathology
Leukemia, Myeloid, Acute - surgery
Male
Maximum Tolerated Dose
Middle Aged
myeloablative conditioning
Prognosis
Prospective Studies
randomized trial
reduced‐intensity conditioning
Severity of Illness Index
Statistics, Nonparametric
Survival Analysis
toxicity
Transplantation Conditioning - methods
Transplantation, Homologous - methods
Treatment Outcome
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Zusammenfassung:Background To our knowledge, no randomized toxicity studies have been conducted to compare myeloablative conditioning (MAC) and reduced‐intensity conditioning (RIC) in allogeneic haematopoietic stem cell transplantation (HSCT). Methods Adult patients ≤60 years of age with myeloid leukaemia were randomly assigned (1 : 1) to treatment with RIC (n = 18) or MAC (n = 19) in this Phase II single‐centre toxicity study. Results There was a maximum median mucositis grade of 1 in the RIC group compared with 4 in the MAC group (P 
ISSN:0954-6820
1365-2796
DOI:10.1111/joim.12056