Immunoglobulin (Ig)M antibodies against oxidized cardiolipin but not native cardiolipin are novel biomarkers in haemodialysis patients, associated negatively with mortality

Summary The risk of premature death is high in haemodialysis (HD) patients. Antibodies against cardiolipin (anti‐CL) are thrombogenic in diseases such as systemic lupus erythematosus (SLE). CL is easily oxidized (Ox) and plays a role in apoptosis. In this work we studied immunoglobulin (Ig)M anti‐CL and anti‐OxCL in HD‐patients. We conducted an observational study with a prospective follow‐up examining the relationship between anti‐CL, anti‐OxCL and mortality risk in a well‐characterized cohort of 221 prevalent HD patients [56% men, median age 66 (interquartile range 51–74) years, vintage time 29 (15–58) months] with a mean follow‐up period of 41 (20–48 months). According to the receiver operator characteristic (ROC) analysis, anti‐OxCL [area under the curve (AUC) 0·62, P