The AGE–RAGE Pathway and Its Relation to Cardiovascular Disease in Patients with Chronic Kidney Disease
Chronic kidney disease (CKD) carries an unequivocal high risk for cardiovascular disease (CVD) contributing to high morbimortality; however, the underlying reasons are not fully known. Among mechanisms involved in the pathophysiology of CVD, chronic overstimulation of the advanced glycation end-prod...
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| Veröffentlicht in: | Archives of medical research 2013-11, Vol.44 (8), p.601-610 |
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| creator | Leurs, Paul Lindholm, Bengt |
| description | Chronic kidney disease (CKD) carries an unequivocal high risk for cardiovascular disease (CVD) contributing to high morbimortality; however, the underlying reasons are not fully known. Among mechanisms involved in the pathophysiology of CVD, chronic overstimulation of the advanced glycation end-products (AGE)–receptor for AGE (RAGE) pathway is likely a major contributor in patients with CKD. This review describes briefly some of the components of this pathway, highlighting especially differences between circulating AGE and tissue AGE and how activation of the AGE–RAGE pathway may promote CVD in CKD. |
| doi_str_mv | 10.1016/j.arcmed.2013.11.002 |
| format | Article |
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Among mechanisms involved in the pathophysiology of CVD, chronic overstimulation of the advanced glycation end-products (AGE)–receptor for AGE (RAGE) pathway is likely a major contributor in patients with CKD. This review describes briefly some of the components of this pathway, highlighting especially differences between circulating AGE and tissue AGE and how activation of the AGE–RAGE pathway may promote CVD in CKD.</description><identifier>ISSN: 0188-4409</identifier><identifier>ISSN: 1873-5487</identifier><identifier>EISSN: 1873-5487</identifier><identifier>DOI: 10.1016/j.arcmed.2013.11.002</identifier><identifier>PMID: 24231387</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cardiovascular Diseases - complications ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - mortality ; Glycation End Products, Advanced - metabolism ; Glycation End Products, Advanced - physiology ; Humans ; Internal Medicine ; Medicin och hälsovetenskap ; Morbidity ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic - biosynthesis ; Receptors, Immunologic - metabolism ; Receptors, Immunologic - physiology ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - metabolism ; Renal Insufficiency, Chronic - mortality ; Risk Factors ; Signal Transduction - physiology</subject><ispartof>Archives of medical research, 2013-11, Vol.44 (8), p.601-610</ispartof><rights>IMSS</rights><rights>2013 IMSS</rights><rights>Copyright © 2013 IMSS. 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Among mechanisms involved in the pathophysiology of CVD, chronic overstimulation of the advanced glycation end-products (AGE)–receptor for AGE (RAGE) pathway is likely a major contributor in patients with CKD. This review describes briefly some of the components of this pathway, highlighting especially differences between circulating AGE and tissue AGE and how activation of the AGE–RAGE pathway may promote CVD in CKD.</description><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Glycation End Products, Advanced - metabolism</subject><subject>Glycation End Products, Advanced - physiology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicin och hälsovetenskap</subject><subject>Morbidity</subject><subject>Receptor for Advanced Glycation End Products</subject><subject>Receptors, Immunologic - biosynthesis</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Immunologic - physiology</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - metabolism</subject><subject>Renal Insufficiency, Chronic - mortality</subject><subject>Risk Factors</subject><subject>Signal Transduction - physiology</subject><issn>0188-4409</issn><issn>1873-5487</issn><issn>1873-5487</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQhy0EokvhDRDykUuCJ_Gf5IJUbUupqAQqe7ccZ6r1NhsvdtLV3ngH3pAnwVF2QUJCnGzZ3zcj-zeEvAaWAwP5bpObYLfY5gWDMgfIGSuekAVUqswEr9RTsmBQVRnnrD4jL2LcMMYqLtVzclbwooSyUgviVmukF9dXP7__uEsL_WKG9d4cqOlbejNEeoedGZzv6eDp0oTW-UcT7diZQC9dRBORun6yHPYJ37thTZfr4Htn6SfX9ng4cS_Js3vTRXx1XM_J6sPVavkxu_18fbO8uM2sYGLIbM25AM6MqRrVWKxkIQ2o9JK6NaaupRRSiVo2DbMgS8kFZ6xWVkkpW1OU5ySby8Y97sZG74LbmnDQ3jh9PHpIO9SiEBJ44ut_8rvg2z_SSYRC1RUoLpP7dnYT-G3EOOitixa7zvTox6iBS1kqxYVKKJ9RG3yMAe9_NwKmpzz1Rs956ilPDaBTnkl7c-wwNtPdSToFmID3M4DpSx8dBh1tisJi6wLaQbfe_a_D3wVs51J6pnvAA8aNH0Of4tKgY6GZ_jrN1DRSUCZbiqr8Bf34yA8</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Leurs, Paul</creator><creator>Lindholm, Bengt</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20131101</creationdate><title>The AGE–RAGE Pathway and Its Relation to Cardiovascular Disease in Patients with Chronic Kidney Disease</title><author>Leurs, Paul ; Lindholm, Bengt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-c9445140aa8b7bce8626a171889daa9966567596bb0c16364540097c7666da23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Cardiovascular Diseases - complications</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Glycation End Products, Advanced - metabolism</topic><topic>Glycation End Products, Advanced - physiology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicin och hälsovetenskap</topic><topic>Morbidity</topic><topic>Receptor for Advanced Glycation End Products</topic><topic>Receptors, Immunologic - biosynthesis</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Receptors, Immunologic - physiology</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - metabolism</topic><topic>Renal Insufficiency, Chronic - mortality</topic><topic>Risk Factors</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leurs, Paul</creatorcontrib><creatorcontrib>Lindholm, Bengt</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Archives of medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leurs, Paul</au><au>Lindholm, Bengt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The AGE–RAGE Pathway and Its Relation to Cardiovascular Disease in Patients with Chronic Kidney Disease</atitle><jtitle>Archives of medical research</jtitle><addtitle>Arch Med Res</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>44</volume><issue>8</issue><spage>601</spage><epage>610</epage><pages>601-610</pages><issn>0188-4409</issn><issn>1873-5487</issn><eissn>1873-5487</eissn><abstract>Chronic kidney disease (CKD) carries an unequivocal high risk for cardiovascular disease (CVD) contributing to high morbimortality; however, the underlying reasons are not fully known. 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| fulltext | fulltext |
| identifier | ISSN: 0188-4409 |
| ispartof | Archives of medical research, 2013-11, Vol.44 (8), p.601-610 |
| issn | 0188-4409 1873-5487 1873-5487 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Cardiovascular Diseases - complications Cardiovascular Diseases - metabolism Cardiovascular Diseases - mortality Glycation End Products, Advanced - metabolism Glycation End Products, Advanced - physiology Humans Internal Medicine Medicin och hälsovetenskap Morbidity Receptor for Advanced Glycation End Products Receptors, Immunologic - biosynthesis Receptors, Immunologic - metabolism Receptors, Immunologic - physiology Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - mortality Risk Factors Signal Transduction - physiology |
| title | The AGE–RAGE Pathway and Its Relation to Cardiovascular Disease in Patients with Chronic Kidney Disease |
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