The AGE–RAGE Pathway and Its Relation to Cardiovascular Disease in Patients with Chronic Kidney Disease

Chronic kidney disease (CKD) carries an unequivocal high risk for cardiovascular disease (CVD) contributing to high morbimortality; however, the underlying reasons are not fully known. Among mechanisms involved in the pathophysiology of CVD, chronic overstimulation of the advanced glycation end-prod...

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Veröffentlicht in:	Archives of medical research 2013-11, Vol.44 (8), p.601-610
Hauptverfasser:	Leurs, Paul, Lindholm, Bengt
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiovascular Diseases - complications Cardiovascular Diseases - metabolism Cardiovascular Diseases - mortality Glycation End Products, Advanced - metabolism Glycation End Products, Advanced - physiology Humans Internal Medicine Medicin och hälsovetenskap Morbidity Receptor for Advanced Glycation End Products Receptors, Immunologic - biosynthesis Receptors, Immunologic - metabolism Receptors, Immunologic - physiology Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - mortality Risk Factors Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	Chronic kidney disease (CKD) carries an unequivocal high risk for cardiovascular disease (CVD) contributing to high morbimortality; however, the underlying reasons are not fully known. Among mechanisms involved in the pathophysiology of CVD, chronic overstimulation of the advanced glycation end-products (AGE)–receptor for AGE (RAGE) pathway is likely a major contributor in patients with CKD. This review describes briefly some of the components of this pathway, highlighting especially differences between circulating AGE and tissue AGE and how activation of the AGE–RAGE pathway may promote CVD in CKD.
ISSN:	0188-4409 1873-5487 1873-5487
DOI:	10.1016/j.arcmed.2013.11.002