A European patient record study on diagnosis and treatment of chemotherapy-induced anaemia

Purpose Patients with cancer frequently experience chemotherapy-induced anaemia (CIA) and iron deficiency. Erythropoiesis-stimulating agents (ESAs), iron supplementation and blood transfusions are available therapies. This study evaluated routine practice in CIA management. Methods Medical oncologis...

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Veröffentlicht in:Supportive care in cancer 2014-08, Vol.22 (8), p.2197-2206
Hauptverfasser: Ludwig, Heinz, Aapro, M., Bokemeyer, C., Glaspy, J., Hedenus, M., Littlewood, T.J., Österborg, A., Rzychon, B., Mitchell, D., Beguin, Y.
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Sprache:eng
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Zusammenfassung:Purpose Patients with cancer frequently experience chemotherapy-induced anaemia (CIA) and iron deficiency. Erythropoiesis-stimulating agents (ESAs), iron supplementation and blood transfusions are available therapies. This study evaluated routine practice in CIA management. Methods Medical oncologists and/or haematologists from nine European countries ( n  = 375) were surveyed on their last five cancer patients treated for CIA ( n  = 1,730). Information was collected on tests performed at diagnosis of anaemia, levels of haemoglobin (Hb), serum ferritin and transferrin saturation (TSAT), as well as applied anaemia therapies. Results Diagnostic tests and therapies for CIA varied across Europe. Anaemia and iron status were mainly assessed by Hb (94 %) and ferritin (48 %) measurements. TSAT was only tested in 14 %. At anaemia diagnosis, 74 % of patients had Hb ≤10 g/dL, including 15 % with severe anaemia (Hb
ISSN:0941-4355
1433-7339
1433-7339
DOI:10.1007/s00520-014-2189-0