Genetic defects in B-cell development and their clinical consequences

Expression of selected genes in hematopoietic stem cells has been identified as a regulator of differentiation of B cells in the liver and bone marrow. Moreover, naïve B cells expressing surface immunoglobulin need other types of genes for antigen-dependent development in secondary lymphoid organs....

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Veröffentlicht in:	Journal of investigational allergology & clinical immunology 2014, Vol.24 (1), p.6-22; quiz 2 p following 22
Hauptverfasser:	Abolhassani, H, Parvaneh, N, Rezaei, N, Hammarström, L, Aghamohammadi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - physiology Bone Marrow Cells - cytology Bone Marrow Cells - immunology Bone Marrow Cells - physiology Cell Differentiation - genetics Cell Differentiation - immunology Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - physiology Humans Lymphocyte Activation Medicin och hälsovetenskap
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Zusammenfassung:	Expression of selected genes in hematopoietic stem cells has been identified as a regulator of differentiation of B cells in the liver and bone marrow. Moreover, naïve B cells expressing surface immunoglobulin need other types of genes for antigen-dependent development in secondary lymphoid organs. Many advanced molecular mechanisms underlying primary antibody deficiencies in humans have been described. We provide an overview of the mutations in genes known to be involved in B-cell development and their clinical consequences.
ISSN:	1018-9068