Epigenetic mechanisms of importance for drug treatment

Highlights • Epigenetic modifications are induced by drugs and other xenobiotics. • Epigenomic variations cause altered drug responses. • Epigenomic biomarkers can aid in drug therapy.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2014-08, Vol.35 (8), p.384-396
Hauptverfasser:	Ivanov, Maxim, Barragan, Isabel, Ingelman-Sundberg, Magnus
Format:	Artikel
Sprache:	eng
Schlagworte:	5-hydroxymethylcytosine Advanced Basic Science Animals DNA methylation Drug Therapy epidrugs Epigenesis, Genetic - drug effects Epigenesis, Genetic - physiology epigenetic editing histone modifications Humans pharmacoepigenetics Pharmacogenetics
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • Epigenetic modifications are induced by drugs and other xenobiotics. • Epigenomic variations cause altered drug responses. • Epigenomic biomarkers can aid in drug therapy.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2014.05.004