Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways

Reactive oxygen species (ROS) participate in the pathogenesis of emphysema. Among ROS‐producing enzymes, NOX NADPH oxidases are thought to be responsible for tissue injury associated with several lung pathologies. To determine whether NOX2 and/or NOX1 participate in the development of emphysema, the...

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Veröffentlicht in:	The Journal of pathology 2015-01, Vol.235 (1), p.65-78
Hauptverfasser:	Trocme, Candice, Deffert, Christine, Cachat, Julien, Donati, Yves, Tissot, Christelle, Papacatzis, Sylvie, Braunersreuther, Vincent, Pache, Jean-Claude, Krause, Karl-Heinz, Holmdahl, Rikard, Barazzone-Argiroffo, Constance, Carnesecchi, Stéphanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals emphysema Humans Inflammation - pathology Lung - pathology macrophages Macrophages - metabolism Macrophages - pathology Matrix Metalloproteinase 9 - metabolism Medicin och hälsovetenskap Membrane Glycoproteins - metabolism Mice MMP-9 NADPH Oxidase 2 NADPH Oxidases - metabolism Neutrophils - pathology NOX2 Original Papers Pulmonary Emphysema - metabolism Pulmonary Emphysema - pathology Reactive Oxygen Species - metabolism ROS SIRT1 Sirtuin 1 - metabolism
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