α7 Nicotinic Acetylcholine Receptor Is Expressed in Human Atherosclerosis and Inhibits Disease in Mice—Brief Report

OBJECTIVE—Cholinergic pathways of the autonomic nervous system are known to modulate inflammation. Because atherosclerosis is a chronic inflammatory condition, we tested whether cholinergic signaling operates in this disease. We have analyzed the expression of the α7 nicotinic acetylcholine receptor...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2014-12, Vol.34 (12), p.2632-2636
Hauptverfasser:	Johansson, Maria E, Ulleryd, Marcus A, Bernardi, Angelina, Lundberg, Anna M, Andersson, Annica, Folkersen, Lasse, Fogelstrand, Linda, Islander, Ulrika, Yan, Zhong-qun, Hansson, Göran K
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha7 Nicotinic Acetylcholine Receptor - deficiency alpha7 Nicotinic Acetylcholine Receptor - genetics alpha7 Nicotinic Acetylcholine Receptor - metabolism Animals Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Bone Marrow Transplantation Carotid Stenosis - genetics Carotid Stenosis - metabolism Carotid Stenosis - pathology Disease Models, Animal Humans Hypercholesterolemia - genetics Hypercholesterolemia - metabolism Macrophages - metabolism Male Medicin och hälsovetenskap Mice Mice, Inbred C57BL Mice, Knockout Receptors, LDL - deficiency Receptors, LDL - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction T-Lymphocytes - metabolism Transplantation Chimera
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