The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies

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Veröffentlicht in:	BRITISH JOURNAL OF HAEMATOLOGY 2015-05, Vol.169 (3), p.455-458
Hauptverfasser:	Daneshmanesh, Amir Hossein, Hojjat‐Farsangi, Mohammad, Moshfegh, Ali, Khan, Abdul Salam, Mikaelsson, Eva, Österborg, Anders, Mellstedt, Håkan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology apoptosis Apoptosis - drug effects chronic lymphocytic leukaemia Humans Leukemia, Lymphocytic, Chronic, B-Cell - metabolism monoclonal antibodies Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT/mTOR pathway Proto-Oncogene Proteins c-akt - metabolism Receptor Tyrosine Kinase-like Orphan Receptors - antagonists & inhibitors ROR1 Signal Transduction - drug effects TOR Serine-Threonine Kinases - metabolism
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