Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence
Background Component-resolved diagnosis might improve the prediction of future allergy in young children. Objective We sought to investigate the association between IgE reactivity to the pathogenesis-related class 10 (PR-10) protein family and allergic rhinitis to birch pollen (ARbp ) from early chi...
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| creator | Westman, Marit, MD Lupinek, Christian, MD Bousquet, Jean, MD, PhD Andersson, Niklas, MSc Pahr, Sandra, MSc Baar, Alexandra, PhD Bergström, Anna, PhD Holmström, Mats, MD, PhD Stjärne, Pär, MD, PhD Lødrup Carlsen, Karin C., MD, PhD Carlsen, Kaj-Håkon, MD, PhD Antó, Josep M., MD, PhD Valenta, Rudolf, MD, PhD van Hage, Marianne, MD, PhD Wickman, Magnus, MD, PhD |
| description | Background Component-resolved diagnosis might improve the prediction of future allergy in young children. Objective We sought to investigate the association between IgE reactivity to the pathogenesis-related class 10 (PR-10) protein family and allergic rhinitis to birch pollen (ARbp ) from early childhood up to age 16 years. Method Questionnaire data and sera obtained at 4, 8, and 16 years of age from the Barn/Children Allergi/Allergy Milieu Stockholm Epidemiologic (BAMSE) study birth cohort were used. Sera from 764 children were analyzed for IgE reactivity to 9 PR-10 allergen proteins at the 3 time points by using an allergen chip based on ISAC technology. ARbp was defined as upper airway symptoms during birch pollen exposure. Results IgE reactivity to Bet v 1 was found in 12%, 17%, and 25% of children at 4, 8, and 16 years of age. IgE reactivity of PR-10 proteins showed a hierarchic intrarelationship: Bet v 1 > Mal d 1 > Cor a 1.04 > Ara h 8 > Pru p 1 > Aln g 1 > Api g 1 > Act d 8 > Gly m 4. There was an increased risk of incidence and persistence of ARbp up to age 16 years with increasing levels of Bet v 1–specific IgE or increasing numbers of IgE-reactive PR-10 proteins at 4 years. Children with severe ARbp at age 16 years had higher levels of Bet v 1–specific IgE at age 4 years compared with children with mild symptoms. Conclusion ARbp at age 16 years can be predicted by analysis of IgE reactivity to PR-10 proteins in early childhood. |
| doi_str_mv | 10.1016/j.jaci.2014.10.042 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_516703</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S009167491401584X</els_id><sourcerecordid>1680179972</sourcerecordid><originalsourceid>FETCH-LOGICAL-c713t-ee19a1cc6686dee9caedd25f6bccad987819f84350412435d7b644c010d096ce3</originalsourceid><addsrcrecordid>eNqFkkGPEyEUxydG49bVL-DBkHhZD1OBYRhIzCabTXU32cSDmngjFF47dOlQgdb028ukdXV70BPw-P0fj_f-VfWa4CnBhL9fTVfauCnFhJXAFDP6pJoQLLuaC9o-rSYYS1Lzjsmz6kVKK1zOjZDPqzPatlQ0nEyqONPR75Hpnbd9CBbdLmcogjbZ7VzeoxzQRuc-LGGA5FIdwesMFhmvU0IEo00MGdyQygasMzkh7T3EpTMo9m5w2SXkBqRt8JAMDAZeVs8W2id4dVzPq28fZ1-vb-q7z59ur6_uatORJtcARGpiDOeCWwBpNFhL2wWfG6OtFJ0gciFY02JGaFlsN-eMGUywxZIbaM6r-pA3_YTNdq420a113KugnTqG7ssOVEt4h5vCXx74crMGW2rNUftHssc3g-vVMuwUb2XXsLYkeHdI0J_Ibq7u1BjDlDAuGrkjhb04PhbDjy2krNautMd7PUDYJkW6pkxIMoz_j3KBSSdlRwv69gRdhW0cSpdHishOCMELRQ-UiSGlCIuHYglWo7PUSo3OUqOzxlhxVhG9-bs7D5LfVirAhwMAZaY7B1El48Z5WxfBZGWD-3f-yxO58cU-Rvt72EP68w-VqMLqy-jt0dqEYdIK9r35BWkD9Z8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1681978886</pqid></control><display><type>article</type><title>Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>SWEPUB Freely available online</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Westman, Marit, MD ; Lupinek, Christian, MD ; Bousquet, Jean, MD, PhD ; Andersson, Niklas, MSc ; Pahr, Sandra, MSc ; Baar, Alexandra, PhD ; Bergström, Anna, PhD ; Holmström, Mats, MD, PhD ; Stjärne, Pär, MD, PhD ; Lødrup Carlsen, Karin C., MD, PhD ; Carlsen, Kaj-Håkon, MD, PhD ; Antó, Josep M., MD, PhD ; Valenta, Rudolf, MD, PhD ; van Hage, Marianne, MD, PhD ; Wickman, Magnus, MD, PhD</creator><creatorcontrib>Westman, Marit, MD ; Lupinek, Christian, MD ; Bousquet, Jean, MD, PhD ; Andersson, Niklas, MSc ; Pahr, Sandra, MSc ; Baar, Alexandra, PhD ; Bergström, Anna, PhD ; Holmström, Mats, MD, PhD ; Stjärne, Pär, MD, PhD ; Lødrup Carlsen, Karin C., MD, PhD ; Carlsen, Kaj-Håkon, MD, PhD ; Antó, Josep M., MD, PhD ; Valenta, Rudolf, MD, PhD ; van Hage, Marianne, MD, PhD ; Wickman, Magnus, MD, PhD ; Mechanisms for the Development of Allergies (MeDALL) consortium ; Mechanisms for the Development of Allergies Consortium</creatorcontrib><description>Background Component-resolved diagnosis might improve the prediction of future allergy in young children. Objective We sought to investigate the association between IgE reactivity to the pathogenesis-related class 10 (PR-10) protein family and allergic rhinitis to birch pollen (ARbp ) from early childhood up to age 16 years. Method Questionnaire data and sera obtained at 4, 8, and 16 years of age from the Barn/Children Allergi/Allergy Milieu Stockholm Epidemiologic (BAMSE) study birth cohort were used. Sera from 764 children were analyzed for IgE reactivity to 9 PR-10 allergen proteins at the 3 time points by using an allergen chip based on ISAC technology. ARbp was defined as upper airway symptoms during birch pollen exposure. Results IgE reactivity to Bet v 1 was found in 12%, 17%, and 25% of children at 4, 8, and 16 years of age. IgE reactivity of PR-10 proteins showed a hierarchic intrarelationship: Bet v 1 > Mal d 1 > Cor a 1.04 > Ara h 8 > Pru p 1 > Aln g 1 > Api g 1 > Act d 8 > Gly m 4. There was an increased risk of incidence and persistence of ARbp up to age 16 years with increasing levels of Bet v 1–specific IgE or increasing numbers of IgE-reactive PR-10 proteins at 4 years. Children with severe ARbp at age 16 years had higher levels of Bet v 1–specific IgE at age 4 years compared with children with mild symptoms. Conclusion ARbp at age 16 years can be predicted by analysis of IgE reactivity to PR-10 proteins in early childhood.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2014.10.042</identifier><identifier>PMID: 25528361</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Age ; Age Factors ; Allergen components ; allergic rhinitis ; Allergies ; Allergology ; Allergy and Immunology ; Antigens, Plant - immunology ; Asthma ; BAMSE ; birch pollen ; Child ; Child, Preschool ; Cluster Analysis ; cohort ; Cohort Studies ; Cross Reactions - immunology ; cross-reactivity ; Families & family life ; Humans ; IgE ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; Immunology ; Incidence ; Life Sciences ; MeDALL ; microarray ; oral allergy syndrome ; Pathogenesis ; Pollen ; Prognosis ; Proteins ; Questionnaires ; Rhinitis, Allergic - diagnosis ; Rhinitis, Allergic - epidemiology ; Rhinitis, Allergic - immunology ; Seroepidemiologic Studies ; Sweden - epidemiology</subject><ispartof>Journal of allergy and clinical immunology, 2015-05, Vol.135 (5), p.1199-1206.e11</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2014 American Academy of Allergy, Asthma & Immunology</rights><rights>Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited May 2015</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c713t-ee19a1cc6686dee9caedd25f6bccad987819f84350412435d7b644c010d096ce3</citedby><cites>FETCH-LOGICAL-c713t-ee19a1cc6686dee9caedd25f6bccad987819f84350412435d7b644c010d096ce3</cites><orcidid>0000-0003-0041-4249 ; 0000-0002-4061-4766 ; 0000-0001-5494-5374</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2014.10.042$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,551,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25528361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.umontpellier.fr/hal-02146839$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:131266201$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Westman, Marit, MD</creatorcontrib><creatorcontrib>Lupinek, Christian, MD</creatorcontrib><creatorcontrib>Bousquet, Jean, MD, PhD</creatorcontrib><creatorcontrib>Andersson, Niklas, MSc</creatorcontrib><creatorcontrib>Pahr, Sandra, MSc</creatorcontrib><creatorcontrib>Baar, Alexandra, PhD</creatorcontrib><creatorcontrib>Bergström, Anna, PhD</creatorcontrib><creatorcontrib>Holmström, Mats, MD, PhD</creatorcontrib><creatorcontrib>Stjärne, Pär, MD, PhD</creatorcontrib><creatorcontrib>Lødrup Carlsen, Karin C., MD, PhD</creatorcontrib><creatorcontrib>Carlsen, Kaj-Håkon, MD, PhD</creatorcontrib><creatorcontrib>Antó, Josep M., MD, PhD</creatorcontrib><creatorcontrib>Valenta, Rudolf, MD, PhD</creatorcontrib><creatorcontrib>van Hage, Marianne, MD, PhD</creatorcontrib><creatorcontrib>Wickman, Magnus, MD, PhD</creatorcontrib><creatorcontrib>Mechanisms for the Development of Allergies (MeDALL) consortium</creatorcontrib><creatorcontrib>Mechanisms for the Development of Allergies Consortium</creatorcontrib><title>Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Component-resolved diagnosis might improve the prediction of future allergy in young children. Objective We sought to investigate the association between IgE reactivity to the pathogenesis-related class 10 (PR-10) protein family and allergic rhinitis to birch pollen (ARbp ) from early childhood up to age 16 years. Method Questionnaire data and sera obtained at 4, 8, and 16 years of age from the Barn/Children Allergi/Allergy Milieu Stockholm Epidemiologic (BAMSE) study birth cohort were used. Sera from 764 children were analyzed for IgE reactivity to 9 PR-10 allergen proteins at the 3 time points by using an allergen chip based on ISAC technology. ARbp was defined as upper airway symptoms during birch pollen exposure. Results IgE reactivity to Bet v 1 was found in 12%, 17%, and 25% of children at 4, 8, and 16 years of age. IgE reactivity of PR-10 proteins showed a hierarchic intrarelationship: Bet v 1 > Mal d 1 > Cor a 1.04 > Ara h 8 > Pru p 1 > Aln g 1 > Api g 1 > Act d 8 > Gly m 4. There was an increased risk of incidence and persistence of ARbp up to age 16 years with increasing levels of Bet v 1–specific IgE or increasing numbers of IgE-reactive PR-10 proteins at 4 years. Children with severe ARbp at age 16 years had higher levels of Bet v 1–specific IgE at age 4 years compared with children with mild symptoms. Conclusion ARbp at age 16 years can be predicted by analysis of IgE reactivity to PR-10 proteins in early childhood.</description><subject>Adolescent</subject><subject>Age</subject><subject>Age Factors</subject><subject>Allergen components</subject><subject>allergic rhinitis</subject><subject>Allergies</subject><subject>Allergology</subject><subject>Allergy and Immunology</subject><subject>Antigens, Plant - immunology</subject><subject>Asthma</subject><subject>BAMSE</subject><subject>birch pollen</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cluster Analysis</subject><subject>cohort</subject><subject>Cohort Studies</subject><subject>Cross Reactions - immunology</subject><subject>cross-reactivity</subject><subject>Families & family life</subject><subject>Humans</subject><subject>IgE</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunology</subject><subject>Incidence</subject><subject>Life Sciences</subject><subject>MeDALL</subject><subject>microarray</subject><subject>oral allergy syndrome</subject><subject>Pathogenesis</subject><subject>Pollen</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Questionnaires</subject><subject>Rhinitis, Allergic - diagnosis</subject><subject>Rhinitis, Allergic - epidemiology</subject><subject>Rhinitis, Allergic - immunology</subject><subject>Seroepidemiologic Studies</subject><subject>Sweden - epidemiology</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqFkkGPEyEUxydG49bVL-DBkHhZD1OBYRhIzCabTXU32cSDmngjFF47dOlQgdb028ukdXV70BPw-P0fj_f-VfWa4CnBhL9fTVfauCnFhJXAFDP6pJoQLLuaC9o-rSYYS1Lzjsmz6kVKK1zOjZDPqzPatlQ0nEyqONPR75Hpnbd9CBbdLmcogjbZ7VzeoxzQRuc-LGGA5FIdwesMFhmvU0IEo00MGdyQygasMzkh7T3EpTMo9m5w2SXkBqRt8JAMDAZeVs8W2id4dVzPq28fZ1-vb-q7z59ur6_uatORJtcARGpiDOeCWwBpNFhL2wWfG6OtFJ0gciFY02JGaFlsN-eMGUywxZIbaM6r-pA3_YTNdq420a113KugnTqG7ssOVEt4h5vCXx74crMGW2rNUftHssc3g-vVMuwUb2XXsLYkeHdI0J_Ibq7u1BjDlDAuGrkjhb04PhbDjy2krNautMd7PUDYJkW6pkxIMoz_j3KBSSdlRwv69gRdhW0cSpdHishOCMELRQ-UiSGlCIuHYglWo7PUSo3OUqOzxlhxVhG9-bs7D5LfVirAhwMAZaY7B1El48Z5WxfBZGWD-3f-yxO58cU-Rvt72EP68w-VqMLqy-jt0dqEYdIK9r35BWkD9Z8</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Westman, Marit, MD</creator><creator>Lupinek, Christian, MD</creator><creator>Bousquet, Jean, MD, PhD</creator><creator>Andersson, Niklas, MSc</creator><creator>Pahr, Sandra, MSc</creator><creator>Baar, Alexandra, PhD</creator><creator>Bergström, Anna, PhD</creator><creator>Holmström, Mats, MD, PhD</creator><creator>Stjärne, Pär, MD, PhD</creator><creator>Lødrup Carlsen, Karin C., MD, PhD</creator><creator>Carlsen, Kaj-Håkon, MD, PhD</creator><creator>Antó, Josep M., MD, PhD</creator><creator>Valenta, Rudolf, MD, PhD</creator><creator>van Hage, Marianne, MD, PhD</creator><creator>Wickman, Magnus, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-0041-4249</orcidid><orcidid>https://orcid.org/0000-0002-4061-4766</orcidid><orcidid>https://orcid.org/0000-0001-5494-5374</orcidid></search><sort><creationdate>20150501</creationdate><title>Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence</title><author>Westman, Marit, MD ; Lupinek, Christian, MD ; Bousquet, Jean, MD, PhD ; Andersson, Niklas, MSc ; Pahr, Sandra, MSc ; Baar, Alexandra, PhD ; Bergström, Anna, PhD ; Holmström, Mats, MD, PhD ; Stjärne, Pär, MD, PhD ; Lødrup Carlsen, Karin C., MD, PhD ; Carlsen, Kaj-Håkon, MD, PhD ; Antó, Josep M., MD, PhD ; Valenta, Rudolf, MD, PhD ; van Hage, Marianne, MD, PhD ; Wickman, Magnus, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c713t-ee19a1cc6686dee9caedd25f6bccad987819f84350412435d7b644c010d096ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Age Factors</topic><topic>Allergen components</topic><topic>allergic rhinitis</topic><topic>Allergies</topic><topic>Allergology</topic><topic>Allergy and Immunology</topic><topic>Antigens, Plant - immunology</topic><topic>Asthma</topic><topic>BAMSE</topic><topic>birch pollen</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cluster Analysis</topic><topic>cohort</topic><topic>Cohort Studies</topic><topic>Cross Reactions - immunology</topic><topic>cross-reactivity</topic><topic>Families & family life</topic><topic>Humans</topic><topic>IgE</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunology</topic><topic>Incidence</topic><topic>Life Sciences</topic><topic>MeDALL</topic><topic>microarray</topic><topic>oral allergy syndrome</topic><topic>Pathogenesis</topic><topic>Pollen</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Questionnaires</topic><topic>Rhinitis, Allergic - diagnosis</topic><topic>Rhinitis, Allergic - epidemiology</topic><topic>Rhinitis, Allergic - immunology</topic><topic>Seroepidemiologic Studies</topic><topic>Sweden - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westman, Marit, MD</creatorcontrib><creatorcontrib>Lupinek, Christian, MD</creatorcontrib><creatorcontrib>Bousquet, Jean, MD, PhD</creatorcontrib><creatorcontrib>Andersson, Niklas, MSc</creatorcontrib><creatorcontrib>Pahr, Sandra, MSc</creatorcontrib><creatorcontrib>Baar, Alexandra, PhD</creatorcontrib><creatorcontrib>Bergström, Anna, PhD</creatorcontrib><creatorcontrib>Holmström, Mats, MD, PhD</creatorcontrib><creatorcontrib>Stjärne, Pär, MD, PhD</creatorcontrib><creatorcontrib>Lødrup Carlsen, Karin C., MD, PhD</creatorcontrib><creatorcontrib>Carlsen, Kaj-Håkon, MD, PhD</creatorcontrib><creatorcontrib>Antó, Josep M., MD, PhD</creatorcontrib><creatorcontrib>Valenta, Rudolf, MD, PhD</creatorcontrib><creatorcontrib>van Hage, Marianne, MD, PhD</creatorcontrib><creatorcontrib>Wickman, Magnus, MD, PhD</creatorcontrib><creatorcontrib>Mechanisms for the Development of Allergies (MeDALL) consortium</creatorcontrib><creatorcontrib>Mechanisms for the Development of Allergies Consortium</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westman, Marit, MD</au><au>Lupinek, Christian, MD</au><au>Bousquet, Jean, MD, PhD</au><au>Andersson, Niklas, MSc</au><au>Pahr, Sandra, MSc</au><au>Baar, Alexandra, PhD</au><au>Bergström, Anna, PhD</au><au>Holmström, Mats, MD, PhD</au><au>Stjärne, Pär, MD, PhD</au><au>Lødrup Carlsen, Karin C., MD, PhD</au><au>Carlsen, Kaj-Håkon, MD, PhD</au><au>Antó, Josep M., MD, PhD</au><au>Valenta, Rudolf, MD, PhD</au><au>van Hage, Marianne, MD, PhD</au><au>Wickman, Magnus, MD, PhD</au><aucorp>Mechanisms for the Development of Allergies (MeDALL) consortium</aucorp><aucorp>Mechanisms for the Development of Allergies Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>135</volume><issue>5</issue><spage>1199</spage><epage>1206.e11</epage><pages>1199-1206.e11</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>Background Component-resolved diagnosis might improve the prediction of future allergy in young children. Objective We sought to investigate the association between IgE reactivity to the pathogenesis-related class 10 (PR-10) protein family and allergic rhinitis to birch pollen (ARbp ) from early childhood up to age 16 years. Method Questionnaire data and sera obtained at 4, 8, and 16 years of age from the Barn/Children Allergi/Allergy Milieu Stockholm Epidemiologic (BAMSE) study birth cohort were used. Sera from 764 children were analyzed for IgE reactivity to 9 PR-10 allergen proteins at the 3 time points by using an allergen chip based on ISAC technology. ARbp was defined as upper airway symptoms during birch pollen exposure. Results IgE reactivity to Bet v 1 was found in 12%, 17%, and 25% of children at 4, 8, and 16 years of age. IgE reactivity of PR-10 proteins showed a hierarchic intrarelationship: Bet v 1 > Mal d 1 > Cor a 1.04 > Ara h 8 > Pru p 1 > Aln g 1 > Api g 1 > Act d 8 > Gly m 4. There was an increased risk of incidence and persistence of ARbp up to age 16 years with increasing levels of Bet v 1–specific IgE or increasing numbers of IgE-reactive PR-10 proteins at 4 years. Children with severe ARbp at age 16 years had higher levels of Bet v 1–specific IgE at age 4 years compared with children with mild symptoms. Conclusion ARbp at age 16 years can be predicted by analysis of IgE reactivity to PR-10 proteins in early childhood.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25528361</pmid><doi>10.1016/j.jaci.2014.10.042</doi><orcidid>https://orcid.org/0000-0003-0041-4249</orcidid><orcidid>https://orcid.org/0000-0002-4061-4766</orcidid><orcidid>https://orcid.org/0000-0001-5494-5374</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of allergy and clinical immunology, 2015-05, Vol.135 (5), p.1199-1206.e11 |
| issn | 0091-6749 1097-6825 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; SWEPUB Freely available online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Age Age Factors Allergen components allergic rhinitis Allergies Allergology Allergy and Immunology Antigens, Plant - immunology Asthma BAMSE birch pollen Child Child, Preschool Cluster Analysis cohort Cohort Studies Cross Reactions - immunology cross-reactivity Families & family life Humans IgE Immunoglobulin E - blood Immunoglobulin E - immunology Immunology Incidence Life Sciences MeDALL microarray oral allergy syndrome Pathogenesis Pollen Prognosis Proteins Questionnaires Rhinitis, Allergic - diagnosis Rhinitis, Allergic - epidemiology Rhinitis, Allergic - immunology Seroepidemiologic Studies Sweden - epidemiology |
| title | Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence |
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