Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies

The role of cytochrome P450 2J2 (CYP2J2) in cyclophosphamide (Cy) bioactivation was investigated in patients, cells and microsomes. Gene expression analysis showed that CYP2J2 mRNA expression was significantly ( P

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Bibliographische Detailangaben
Veröffentlicht in:	The pharmacogenomics journal 2015-10, Vol.15 (5), p.405-413
Hauptverfasser:	El-Serafi, I, Fares, M, Abedi-Valugerdi, M, Afsharian, P, Moshfegh, A, Terelius, Y, Potácová, Z, Hassan, M
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 38/22 38/39 38/77 38/90 692/308/575 Adolescent Adult Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Blood diseases Cell survival Cell viability Child Complications and side effects Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Cytochrome Cytochrome P-450 Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Cytochrome P450 Drug metabolism Female Gene Expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Health aspects Heart - drug effects Hematologic Neoplasms - drug therapy Hematologic Neoplasms - genetics Hematologic Neoplasms - pathology Hematology HL-60 Cells Human Genetics Humans Intestine Intestines - drug effects Intestines - metabolism Male Medicin och hälsovetenskap Metabolism Microsomes Middle Aged Oncology Organs original-article Pharmacotherapy Properties Psychopharmacology Risk factors Stem Cell Transplantation Stem cells Toxicity Transplantation Urinary bladder Urinary Bladder - drug effects Urinary Bladder - metabolism
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Beschreibung
Zusammenfassung:	The role of cytochrome P450 2J2 (CYP2J2) in cyclophosphamide (Cy) bioactivation was investigated in patients, cells and microsomes. Gene expression analysis showed that CYP2J2 mRNA expression was significantly ( P
ISSN:	1470-269X 1473-1150 1473-1150
DOI:	10.1038/tpj.2014.82