Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity

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Veröffentlicht in:	Journal of hepatology 2015-06, Vol.62 (6), p.1398-1404
Hauptverfasser:	Mueller, Michaela, Thorell, Anders, Claudel, Thierry, Jha, Pooja, Koefeler, Harald, Lackner, Carolin, Hoesel, Bastian, Fauler, Guenter, Stojakovic, Tatjana, Einarsson, Curt, Marschall, Hanns-Ulrich, Trauner, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	3-hydroxy-3-methylglutaryl-CoA reductase ADIPOSE-TISSUE Bile Acids and Salts - biosynthesis Bile Acids and Salts - metabolism CHOLESTEROL-METABOLISM COA DESATURASE Endocrinology and Diabetes Endokrinologi och diabetes EXPRESSION FATTY LIVER-DISEASE FEEDBACK-REGULATION FGF19 Gastroenterology & Hepatology Gastroenterology and Hepatology Humans Intra-Abdominal Fat - drug effects Intra-Abdominal Fat - metabolism Lipid Metabolism - drug effects Lipogenesis Liver - drug effects Liver - metabolism Non-alcoholic fatty liver disease Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism NONALCOHOLIC NUCLEAR RECEPTOR Obesity, Morbid - drug therapy Obesity, Morbid - metabolism Oleic Acid - metabolism PLACEBO-CONTROLLED TRIAL Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Stearoyl-CoA desaturase Stearoyl-CoA Desaturase - biosynthesis STEATOHEPATITIS TRANSPORT Ursodeoxycholic Acid - administration & dosage Ursodeoxycholic Acid - pharmacology
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