Acute isoproterenol induces anxiety-like behavior in rats and increases plasma content of extracellular vesicles

Abstract Several clinical observations have demonstrated a link between heart rate and anxiety or panic disorders. In these patients, β-adrenergic receptor function was altered. This prompted us to investigate whether the β-adrenergic receptor agonist isoproterenol, at a dose that stimulates periphe...

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Veröffentlicht in:Physiology & behavior 2015-04, Vol.142, p.79-84
Hauptverfasser: Leo, Giuseppina, Guescini, Michele, Genedani, Susanna, Stocchi, Vilberto, Carone, Chiara, Filaferro, Monica, Sisti, Davide, Marcoli, Manuela, Maura, Guido, Cortelli, Pietro, Guidolin, Diego, Fuxe, Kjell, Agnati, Luigi Francesco
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Sprache:eng
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Zusammenfassung:Abstract Several clinical observations have demonstrated a link between heart rate and anxiety or panic disorders. In these patients, β-adrenergic receptor function was altered. This prompted us to investigate whether the β-adrenergic receptor agonist isoproterenol, at a dose that stimulates peripheral β-adrenergic system but has no effects at the central nervous system, can induce anxiety-like behavior in rats. Moreover, some possible messengers involved in the peripheral to brain communication were investigated. Our results showed that isoproterenol (5 mg kg − 1 i.p.) increased heart rate, evoked anxiety-like behavior, did not result in motor impairments and increased extracellular vesicle content in the blood. Plasma corticosterone level was unmodified as well as vesicular Hsp70 content. Vesicular miR-208 was also unmodified indicating a source of increased extracellular vesicles different from cardiomyocytes. We can hypothesize that peripheral extracellular vesicles might contribute to the β-adrenergic receptor-evoked anxiety-like behavior, acting as peripheral signals in modulating the mental state.
ISSN:0031-9384
1873-507X
1873-507X
DOI:10.1016/j.physbeh.2015.02.002