Primary graft failure after myeloablative allogeneic hematopoietic cell transplantation for hematologic malignancies

Clinical outcomes after primary graft failure (PGF) remain poor. Here we present a large retrospective analysis ( n =23 272) which investigates means to prevent PGF and early detection of patients at high risk. In patients with hematologic malignancies, who underwent their first myeloablative alloge...

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Veröffentlicht in:	Leukemia 2015-08, Vol.29 (8), p.1754-1762
Hauptverfasser:	Olsson, R F, Logan, B R, Chaudhury, S, Zhu, X, Akpek, G, Bolwell, B J, Bredeson, C N, Dvorak, C C, Gupta, V, Ho, V T, Lazarus, H M, Marks, D I, Ringdén, O T H, Pasquini, M C, Schriber, J R, Cooke, K R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/1542 692/499 692/699/67/1990 692/700/565/545/576/1955 ABO system Adolescent Adult Aged Blood cancer Blood diseases Bone marrow Bone marrow transplantation Busulfan Cancer Research Care and treatment Child Child, Preschool Colony-stimulating factor Conditioning Critical Care Medicine Cryopreservation Cyclophosphamide Failure analysis Female Follow-Up Studies Graft rejection Graft Survival Graft vs Host Disease - drug therapy Graft vs Host Disease - etiology Graft vs Host Disease - mortality Grafting Grafts Granulocyte colony-stimulating factor Hematologic Neoplasms - complications Hematologic Neoplasms - mortality Hematologic Neoplasms - therapy Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Histocompatibility antigen HLA Humans Immunosuppression Immunosuppressive agents Immunosuppressive Agents - therapeutic use Incompatibility Infant Infant, Newborn Intensive Internal Medicine Leukemia Leukocytes (granulocytic) Male Medicine Medicine & Public Health Middle Aged Myeloablative Agonists - adverse effects Myeloproliferative diseases Neoplasm Staging Oncology original-article Patient outcomes Peripheral blood Primary Graft Dysfunction - drug therapy Primary Graft Dysfunction - etiology Primary Graft Dysfunction - mortality Prognosis Retrospective Studies Risk analysis Risk factors Risk reduction Stem cell transplantation Stem cells Survival Rate Tacrolimus Transplantation Transplantation Conditioning - adverse effects Transplantation, Homologous Transplants Transplants & implants Young Adult
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