Primary graft failure after myeloablative allogeneic hematopoietic cell transplantation for hematologic malignancies

Clinical outcomes after primary graft failure (PGF) remain poor. Here we present a large retrospective analysis ( n =23 272) which investigates means to prevent PGF and early detection of patients at high risk. In patients with hematologic malignancies, who underwent their first myeloablative alloge...

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Veröffentlicht in:	Leukemia 2015-08, Vol.29 (8), p.1754-1762
Hauptverfasser:	Olsson, R F, Logan, B R, Chaudhury, S, Zhu, X, Akpek, G, Bolwell, B J, Bredeson, C N, Dvorak, C C, Gupta, V, Ho, V T, Lazarus, H M, Marks, D I, Ringdén, O T H, Pasquini, M C, Schriber, J R, Cooke, K R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/1542 692/499 692/699/67/1990 692/700/565/545/576/1955 ABO system Adolescent Adult Aged Blood cancer Blood diseases Bone marrow Bone marrow transplantation Busulfan Cancer Research Care and treatment Child Child, Preschool Colony-stimulating factor Conditioning Critical Care Medicine Cryopreservation Cyclophosphamide Failure analysis Female Follow-Up Studies Graft rejection Graft Survival Graft vs Host Disease - drug therapy Graft vs Host Disease - etiology Graft vs Host Disease - mortality Grafting Grafts Granulocyte colony-stimulating factor Hematologic Neoplasms - complications Hematologic Neoplasms - mortality Hematologic Neoplasms - therapy Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Histocompatibility antigen HLA Humans Immunosuppression Immunosuppressive agents Immunosuppressive Agents - therapeutic use Incompatibility Infant Infant, Newborn Intensive Internal Medicine Leukemia Leukocytes (granulocytic) Male Medicine Medicine & Public Health Middle Aged Myeloablative Agonists - adverse effects Myeloproliferative diseases Neoplasm Staging Oncology original-article Patient outcomes Peripheral blood Primary Graft Dysfunction - drug therapy Primary Graft Dysfunction - etiology Primary Graft Dysfunction - mortality Prognosis Retrospective Studies Risk analysis Risk factors Risk reduction Stem cell transplantation Stem cells Survival Rate Tacrolimus Transplantation Transplantation Conditioning - adverse effects Transplantation, Homologous Transplants Transplants & implants Young Adult
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Zusammenfassung:	Clinical outcomes after primary graft failure (PGF) remain poor. Here we present a large retrospective analysis ( n =23 272) which investigates means to prevent PGF and early detection of patients at high risk. In patients with hematologic malignancies, who underwent their first myeloablative allogeneic hematopoietic cell transplantation, PGF was reported in 1278 (5.5%), and there was a marked difference in PGFs using peripheral blood stem cell compared with bone marrow grafts (2.5 vs 7.3%; P
ISSN:	0887-6924 1476-5551 1476-5551
DOI:	10.1038/leu.2015.75