prospective study of erythrocyte polyunsaturated fatty acid, weight gain, and risk of becoming overweight or obese in middle-aged and older women
PURPOSE: ω3 and ω6 fatty acids (FA) may have divergent effects on the development of obesity. We examined the association of baseline erythrocyte ω3 and ω6 FA composition with body weight change and the risk of becoming overweight or obese in the Women’s Health Study (WHS) participants. METHODS: We...
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| Veröffentlicht in: | European journal of nutrition 2016-03, Vol.55 (2), p.687-697 |
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| creator | Wang, Lu Manson, JoAnn E Rautiainen, Susanne Gaziano, J. Michael Buring, Julie E Tsai, Michael Y Sesso, Howard D |
| description | PURPOSE: ω3 and ω6 fatty acids (FA) may have divergent effects on the development of obesity. We examined the association of baseline erythrocyte ω3 and ω6 FA composition with body weight change and the risk of becoming overweight or obese in the Women’s Health Study (WHS) participants. METHODS: We identified 534 women who had baseline erythrocyte FA measured and a baseline body mass index (BMI) of 18.5– |
| doi_str_mv | 10.1007/s00394-015-0889-y |
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Michael ; Buring, Julie E ; Tsai, Michael Y ; Sesso, Howard D</creator><creatorcontrib>Wang, Lu ; Manson, JoAnn E ; Rautiainen, Susanne ; Gaziano, J. Michael ; Buring, Julie E ; Tsai, Michael Y ; Sesso, Howard D</creatorcontrib><description>PURPOSE: ω3 and ω6 fatty acids (FA) may have divergent effects on the development of obesity. We examined the association of baseline erythrocyte ω3 and ω6 FA composition with body weight change and the risk of becoming overweight or obese in the Women’s Health Study (WHS) participants. METHODS: We identified 534 women who had baseline erythrocyte FA measured and a baseline body mass index (BMI) of 18.5–<25 kg/m². Body weight was updated at a total of six time points during follow-up. RESULTS: Weight gain during a mean of 10.4-year follow-up increased with increasing quartiles of baseline erythrocyte cis ω6 FA, ω6/ω3 ratio, and trans FA while decreased with increasing cis ω3 FA. After multivariable adjustment including total energy intake and physical activity, the weight gain (kg) in the highest versus the lowest quartile was 3.08 versus 2.32 for erythrocyte cis ω6 FA (p ₜᵣₑₙd 0.04), 2.07 versus 2.92 for cis ω3 FA (p ₜᵣₑₙd 0.08), 2.93 versus 2.05 for ω6/ω3 ratio (p ₜᵣₑₙd 0.046), and 3.03 versus 2.27 for trans FA (p ₜᵣₑₙd 0.06). Among individual FA, the associations were significant for 18:2ω6, 18:3ω6, and trans 18:1 and marginally significant for 20:3ω6 and trans 18:2. The risk of becoming overweight or obese (defined as BMI ≥25 kg/m² at any follow-up time point) increased across increasing ω6/ω3 ratio (multivariable model p ₜᵣₑₙd 0.04). CONCLUSIONS: In this prospective study, we found suggestive evidence that erythrocyte cis ω6 FA may be positively associated, and cis ω3 FA inversely associated with weight gain in initially normal-weight women.</description><identifier>ISSN: 1436-6207</identifier><identifier>ISSN: 1436-6215</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-015-0889-y</identifier><identifier>PMID: 25820817</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>body composition ; Body Mass Index ; Chemistry ; Chemistry and Materials Science ; Energy Intake ; erythrocytes ; Erythrocytes - chemistry ; Fatty Acids, Omega-3 - chemistry ; Fatty Acids, Omega-6 - chemistry ; Female ; Follow-Up Studies ; Humans ; Medicin och hälsovetenskap ; Middle Aged ; middle-aged adults ; Nutrition ; obesity ; Obesity - blood ; omega-6 fatty acids ; Original Contribution ; Overweight - blood ; physical activity ; polyunsaturated fatty acids ; Proportional Hazards Models ; Prospective Studies ; risk ; Risk Factors ; Trans Fatty Acids - chemistry ; Weight Gain ; women</subject><ispartof>European journal of nutrition, 2016-03, Vol.55 (2), p.687-697</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c681t-a2eda64e8b62011d7991497ef9e0c8003514dfc313bf70ece5cbe8021cad27383</citedby><cites>FETCH-LOGICAL-c681t-a2eda64e8b62011d7991497ef9e0c8003514dfc313bf70ece5cbe8021cad27383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-015-0889-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-015-0889-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,552,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25820817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:133083560$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Lu</creatorcontrib><creatorcontrib>Manson, JoAnn E</creatorcontrib><creatorcontrib>Rautiainen, Susanne</creatorcontrib><creatorcontrib>Gaziano, J. Michael</creatorcontrib><creatorcontrib>Buring, Julie E</creatorcontrib><creatorcontrib>Tsai, Michael Y</creatorcontrib><creatorcontrib>Sesso, Howard D</creatorcontrib><title>prospective study of erythrocyte polyunsaturated fatty acid, weight gain, and risk of becoming overweight or obese in middle-aged and older women</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>PURPOSE: ω3 and ω6 fatty acids (FA) may have divergent effects on the development of obesity. We examined the association of baseline erythrocyte ω3 and ω6 FA composition with body weight change and the risk of becoming overweight or obese in the Women’s Health Study (WHS) participants. METHODS: We identified 534 women who had baseline erythrocyte FA measured and a baseline body mass index (BMI) of 18.5–<25 kg/m². Body weight was updated at a total of six time points during follow-up. RESULTS: Weight gain during a mean of 10.4-year follow-up increased with increasing quartiles of baseline erythrocyte cis ω6 FA, ω6/ω3 ratio, and trans FA while decreased with increasing cis ω3 FA. After multivariable adjustment including total energy intake and physical activity, the weight gain (kg) in the highest versus the lowest quartile was 3.08 versus 2.32 for erythrocyte cis ω6 FA (p ₜᵣₑₙd 0.04), 2.07 versus 2.92 for cis ω3 FA (p ₜᵣₑₙd 0.08), 2.93 versus 2.05 for ω6/ω3 ratio (p ₜᵣₑₙd 0.046), and 3.03 versus 2.27 for trans FA (p ₜᵣₑₙd 0.06). Among individual FA, the associations were significant for 18:2ω6, 18:3ω6, and trans 18:1 and marginally significant for 20:3ω6 and trans 18:2. The risk of becoming overweight or obese (defined as BMI ≥25 kg/m² at any follow-up time point) increased across increasing ω6/ω3 ratio (multivariable model p ₜᵣₑₙd 0.04). CONCLUSIONS: In this prospective study, we found suggestive evidence that erythrocyte cis ω6 FA may be positively associated, and cis ω3 FA inversely associated with weight gain in initially normal-weight women.</description><subject>body composition</subject><subject>Body Mass Index</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Energy Intake</subject><subject>erythrocytes</subject><subject>Erythrocytes - chemistry</subject><subject>Fatty Acids, Omega-3 - chemistry</subject><subject>Fatty Acids, Omega-6 - chemistry</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>middle-aged adults</subject><subject>Nutrition</subject><subject>obesity</subject><subject>Obesity - blood</subject><subject>omega-6 fatty acids</subject><subject>Original Contribution</subject><subject>Overweight - blood</subject><subject>physical activity</subject><subject>polyunsaturated fatty acids</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>risk</subject><subject>Risk Factors</subject><subject>Trans Fatty Acids - chemistry</subject><subject>Weight Gain</subject><subject>women</subject><issn>1436-6207</issn><issn>1436-6215</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>D8T</sourceid><recordid>eNqNks1u1DAUhSMEoqXwAGzAEhsWDdhxHDsbJFTxJ1ViAV1bjn2TSZvEg-3MKI_BG3NHMx1aJBCrWPF3jn2PT5Y9Z_QNo1S-jZTyuswpEzlVqs6XB9kpK3mVVwUTD49rKk-yJzFeU0oLXrHH2UkhVEEVk6fZz3XwcQ029RsgMc1uIb4lEJa0Ct4uCcjaD8s8RZPmYBI40pqUFmJs787JFvpulUhn-umcmMmR0MebnUED1o_91BG_gXCgfCC-gQikn8jYOzdAbjo03On84CCQrR9hepo9as0Q4dnhe5Zdffzw_eJzfvn105eL95e5rRRLuSnAmaoE1eCAjDlZ16ysJbQ1UKswGMFK11rOeNNKChaEbUDRglnjCskVP8vyvW_cwnpu9Dr0owmL9qbXh183uAKNRhXnyNd_5TFE91t0K2ScU8VFRVH7bq9FYARnYUrBDPct7u1M_Up3fqNLoXCwAg1eHwyC_zFDTHrso4VhMBP4OWomFRVMCMn-A62UEKXkJaKv_kCv_RwmTB0pySj6qd3gbE9ZrEoM0B7vzaje9VDve6ixh3rXQ72g5sXdgY-K2-IhUBzSxK2pg3Dn6H-4vtyLWuO16bBs-uobvn6FzcacZMl_ATyL9r4</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Wang, Lu</creator><creator>Manson, JoAnn E</creator><creator>Rautiainen, Susanne</creator><creator>Gaziano, J. Michael</creator><creator>Buring, Julie E</creator><creator>Tsai, Michael Y</creator><creator>Sesso, Howard D</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20160301</creationdate><title>prospective study of erythrocyte polyunsaturated fatty acid, weight gain, and risk of becoming overweight or obese in middle-aged and older women</title><author>Wang, Lu ; Manson, JoAnn E ; Rautiainen, Susanne ; Gaziano, J. Michael ; Buring, Julie E ; Tsai, Michael Y ; Sesso, Howard D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c681t-a2eda64e8b62011d7991497ef9e0c8003514dfc313bf70ece5cbe8021cad27383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>body composition</topic><topic>Body Mass Index</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Energy Intake</topic><topic>erythrocytes</topic><topic>Erythrocytes - chemistry</topic><topic>Fatty Acids, Omega-3 - chemistry</topic><topic>Fatty Acids, Omega-6 - chemistry</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>middle-aged adults</topic><topic>Nutrition</topic><topic>obesity</topic><topic>Obesity - blood</topic><topic>omega-6 fatty acids</topic><topic>Original Contribution</topic><topic>Overweight - blood</topic><topic>physical activity</topic><topic>polyunsaturated fatty acids</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>risk</topic><topic>Risk Factors</topic><topic>Trans Fatty Acids - chemistry</topic><topic>Weight Gain</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Lu</creatorcontrib><creatorcontrib>Manson, JoAnn E</creatorcontrib><creatorcontrib>Rautiainen, Susanne</creatorcontrib><creatorcontrib>Gaziano, J. 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Michael</au><au>Buring, Julie E</au><au>Tsai, Michael Y</au><au>Sesso, Howard D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>prospective study of erythrocyte polyunsaturated fatty acid, weight gain, and risk of becoming overweight or obese in middle-aged and older women</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>55</volume><issue>2</issue><spage>687</spage><epage>697</epage><pages>687-697</pages><issn>1436-6207</issn><issn>1436-6215</issn><eissn>1436-6215</eissn><abstract>PURPOSE: ω3 and ω6 fatty acids (FA) may have divergent effects on the development of obesity. We examined the association of baseline erythrocyte ω3 and ω6 FA composition with body weight change and the risk of becoming overweight or obese in the Women’s Health Study (WHS) participants. METHODS: We identified 534 women who had baseline erythrocyte FA measured and a baseline body mass index (BMI) of 18.5–<25 kg/m². Body weight was updated at a total of six time points during follow-up. RESULTS: Weight gain during a mean of 10.4-year follow-up increased with increasing quartiles of baseline erythrocyte cis ω6 FA, ω6/ω3 ratio, and trans FA while decreased with increasing cis ω3 FA. After multivariable adjustment including total energy intake and physical activity, the weight gain (kg) in the highest versus the lowest quartile was 3.08 versus 2.32 for erythrocyte cis ω6 FA (p ₜᵣₑₙd 0.04), 2.07 versus 2.92 for cis ω3 FA (p ₜᵣₑₙd 0.08), 2.93 versus 2.05 for ω6/ω3 ratio (p ₜᵣₑₙd 0.046), and 3.03 versus 2.27 for trans FA (p ₜᵣₑₙd 0.06). Among individual FA, the associations were significant for 18:2ω6, 18:3ω6, and trans 18:1 and marginally significant for 20:3ω6 and trans 18:2. The risk of becoming overweight or obese (defined as BMI ≥25 kg/m² at any follow-up time point) increased across increasing ω6/ω3 ratio (multivariable model p ₜᵣₑₙd 0.04). CONCLUSIONS: In this prospective study, we found suggestive evidence that erythrocyte cis ω6 FA may be positively associated, and cis ω3 FA inversely associated with weight gain in initially normal-weight women.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25820817</pmid><doi>10.1007/s00394-015-0889-y</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | body composition Body Mass Index Chemistry Chemistry and Materials Science Energy Intake erythrocytes Erythrocytes - chemistry Fatty Acids, Omega-3 - chemistry Fatty Acids, Omega-6 - chemistry Female Follow-Up Studies Humans Medicin och hälsovetenskap Middle Aged middle-aged adults Nutrition obesity Obesity - blood omega-6 fatty acids Original Contribution Overweight - blood physical activity polyunsaturated fatty acids Proportional Hazards Models Prospective Studies risk Risk Factors Trans Fatty Acids - chemistry Weight Gain women |
| title | prospective study of erythrocyte polyunsaturated fatty acid, weight gain, and risk of becoming overweight or obese in middle-aged and older women |
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