Meropenem-clavulanic acid has high in vitro activity against multidrug-resistant Mycobacterium tuberculosis

We investigated the activity of meropenem-clavulanic acid (MEM-CLA) against 68 Mycobacterium tuberculosis isolates. We included predominantly multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) isolates, since the activity of MEM-CLA for resistant isolates has previously not been studied...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Antimicrobial agents and chemotherapy 2015, Vol.59 (6), p.3630-3632
Hauptverfasser:	Davies Forsman, L, Giske, C G, Bruchfeld, J, Schön, T, Juréen, P, Ängeby, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents Antitubercular Agents - pharmacology Clavulanic Acid Clavulanic Acid - pharmacology Medicin och hälsovetenskap Microbial Sensitivity Tests Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Susceptibility Thienamycins Thienamycins - pharmacology Tuberculosis, Multidrug-Resistant - microbiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We investigated the activity of meropenem-clavulanic acid (MEM-CLA) against 68 Mycobacterium tuberculosis isolates. We included predominantly multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) isolates, since the activity of MEM-CLA for resistant isolates has previously not been studied extensively. Using Middlebrook 7H10 medium, all but four isolates showed an MIC distribution of 0.125 to 2 mg/liter for MEM-CLA, below the non-species-related breakpoint for MEM of 2 mg/liter defined by EUCAST. MEM-CLA is a potential treatment option for MDR/XDR-TB.
ISSN:	0066-4804 1098-6596 1098-6596
DOI:	10.1128/AAC.00171-15