Ecological effect of ceftazidime/avibactam on the normal human intestinal microbiota

Highlights • Ceftazidime/avibactam is a new β-lactam/β-lactamase inhibitor combination. • Ceftazidime/avibactam was given to 12 healthy volunteers. • Ceftazidime/avibactam had a significant ecological effect on the human intestinal microbiota. • Five volunteers were colonised by Clostridium difficil...

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Veröffentlicht in:	International journal of antimicrobial agents 2015-07, Vol.46 (1), p.60-65
Hauptverfasser:	Rashid, Mamun-Ur, Rosenborg, Staffan, Panagiotidis, Georgios, Löfdal, Karin Söderberg, Weintraub, Andrej, Nord, Carl Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adult Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Azabicyclo Compounds - administration & dosage Azabicyclo Compounds - pharmacokinetics Azabicyclo Compounds - pharmacology Bacteria - classification Bacteria - drug effects Bacteria - isolation & purification Ceftazidime - administration & dosage Ceftazidime - pharmacokinetics Ceftazidime - pharmacology Ceftazidime/avibactam Clostridium difficile Feces - microbiology Female Gastrointestinal Microbiome - drug effects Healthy Volunteers Human intestinal microbiota Humans Infectious Disease Male Microbiota - drug effects Plasma - chemistry Young Adult
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Zusammenfassung:	Highlights • Ceftazidime/avibactam is a new β-lactam/β-lactamase inhibitor combination. • Ceftazidime/avibactam was given to 12 healthy volunteers. • Ceftazidime/avibactam had a significant ecological effect on the human intestinal microbiota. • Five volunteers were colonised by Clostridium difficile.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2015.02.027