Through a Clear Cell, Darkly: HIF2α/PLIN2-Maintained Fat Droplets Protect ccRCCs from ER Stress

Qiu and colleagues describe how a structural component of lipid droplets is markedly induced in pseudohypoxic renal tumors, where it maintains endoplasmic reticulum (ER) homeostasis. This adaptation is indispensable in tumor cells-where growth demands and a fluctuating blood supply place unnatural s...

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Veröffentlicht in:	Cancer discovery 2015-06, Vol.5 (6), p.584-585
Hauptverfasser:	Sim, Jingwei, Johnson, Randall S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - metabolism Carcinoma, Renal Cell - metabolism Endoplasmic Reticulum - metabolism Homeostasis Humans Kidney Neoplasms - metabolism Lipid Metabolism Medicin och hälsovetenskap
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Zusammenfassung:	Qiu and colleagues describe how a structural component of lipid droplets is markedly induced in pseudohypoxic renal tumors, where it maintains endoplasmic reticulum (ER) homeostasis. This adaptation is indispensable in tumor cells-where growth demands and a fluctuating blood supply place unnatural stresses on ER function-and is therefore an attractive therapeutic target.
ISSN:	2159-8274 2159-8290 2159-8290
DOI:	10.1158/2159-8290.CD-15-0480