Towards host-directed therapies for tuberculosis

The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis . A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies. The treatment of tuberculosis is based on combinations of drugs that di...

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Veröffentlicht in:	Nature reviews. Drug discovery 2015-08, Vol.14 (8), p.511-512
Hauptverfasser:	Zumla, Alimuddin, Chakaya, Jeremiah, Hoelscher, Michael, Ntoumi, Francine, Rustomjee, Roxana, Vilaplana, Cristina, Yeboah-Manu, Dorothy, Rasolofo, Voahangy, Munderi, Paula, Singh, Nalini, Aklillu, Eleni, Padayatchi, Nesri, Macete, Eusebio, Kapata, Nathan, Mulenga, Modest, Kibiki, Gibson, Mfinanga, Sayoki, Nyirenda, Thomas, Maboko, Leonard, Garcia-Basteiro, Alberto, Rakotosamimanana, Niaina, Bates, Matthew, Mwaba, Peter, Reither, Klaus, Gagneux, Sebastien, Edwards, Sarah, Mfinanga, Elirehema, Abdulla, Salim, Cardona, Pere-Joan, Russell, James B.W., Gant, Vanya, Noursadeghi, Mahdad, Elkington, Paul, Bonnet, Maryline, Menendez, Clara, Dieye, Tandakha N., Diarra, Bassirou, Maiga, Almoustapha, Aseffa, Abraham, Parida, Shreemanta, Wejse, Christian, Petersen, Eskild, Kaleebu, Pontiano, Oliver, Matt, Craig, Gill, Corrah, Tumena, Tientcheu, Leopold, Antonio, Martin, Rao, Martin, McHugh, Timothy D., Sheikh, Aziz, Ippolito, Giuseppe, Ramjee, Gita, Kaufmann, Stefan H. E., Churchyard, Gavin, Steyn, Andrie, Grobusch, Martin, Sanne, Ian, Martinson, Neil, Madansein, Rajhmun, Wilkinson, Robert J., Mayosi, Bongani, Schito, Marco, Wallis, Robert S., Maeurer, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/109 692/699/255/1856 Antitubercular Agents - administration & dosage Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Biomedical and Life Sciences Biomedicine Biotechnology Cancer Research Care and treatment comment Drug Design Drug Therapy, Combination Humans Innovations Medicinal Chemistry Molecular Medicine Molecular Targeted Therapy Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Pharmacology/Toxicology Precision medicine Tuberculosis Tuberculosis - drug therapy
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Beschreibung
Zusammenfassung:	The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis . A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies. The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis . A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.
ISSN:	1474-1776 1474-1784
DOI:	10.1038/nrd4696