Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms

Highlights • Different kynurenic pathway signatures were evident depending on MS disease course. • Quinolinic acid/kynurenic acid ratio increased in RRMS with acute relapse. • A trend for decreased tryptophan and kynurenic acid in SPMS. • Tryptophan, quinolinic acid and kynurenic acid increased in P...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-01, Vol.51, p.47-55
Hauptverfasser:	Aeinehband, Shahin, Brenner, Philip, Ståhl, Sara, Bhat, Maria, Fidock, Mark D, Khademi, Mohsen, Olsson, Tomas, Engberg, Göran, Jokinen, Jussi, Erhardt, Sophie, Piehl, Fredrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Cerebrospinal fluid Depression Disease Progression Female Humans Kynurenine - cerebrospinal fluid Kynurenine pathway Male Middle Aged Multiple sclerosis Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - complications Progressive MS Psychiatry Tryptophan - cerebrospinal fluid
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Zusammenfassung:	Highlights • Different kynurenic pathway signatures were evident depending on MS disease course. • Quinolinic acid/kynurenic acid ratio increased in RRMS with acute relapse. • A trend for decreased tryptophan and kynurenic acid in SPMS. • Tryptophan, quinolinic acid and kynurenic acid increased in PPMS. • A trend for decreased tryptophan in RRMS patients with depression.
ISSN:	0889-1591 1090-2139 1090-2139
DOI:	10.1016/j.bbi.2015.07.016