Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease

Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT...

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Veröffentlicht in:	Journal of the American Heart Association 2015, Vol.4 (8), p.e001853
Hauptverfasser:	Persson, Jonas, Strawbridge, Rona J, McLeod, Olga, Gertow, Karl, Silveira, Angela, Baldassarre, Damiano, Van Zuydam, Natalie, Shah, Sonia, Fava, Cristiano, Gustafsson, Stefan, Veglia, Fabrizio, Sennblad, Bengt, Larsson, Malin, Sabater-Lleal, Maria, Leander, Karin, Gigante, Bruna, Tabak, Adam, Kivimaki, Mika, Kauhanen, Jussi, Rauramaa, Rainer, Smit, Andries J, Mannarino, Elmo, Giral, Philippe, Humphries, Steve E, Tremoli, Elena, de Faire, Ulf, Lind, Lars, Ingelsson, Erik, Hedblad, Bo, Melander, Olle, Kumari, Meena, Hingorani, Aroon, Morris, Andrew D, Palmer, Colin N A, Lundman, Pia, Öhrvik, John, Söderberg, Stefan, Hamsten, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	adiponectin Adiponectin - blood Adiponectin - genetics Aged atherosclerosis Biomarkers - blood Cardiac and Cardiovascular Systems Carotid Artery Diseases - blood Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - epidemiology Carotid Artery Diseases - genetics Carotid Artery, Common - diagnostic imaging Carotid Intima-Media Thickness Clinical Medicine Disease Progression Europe - epidemiology Female Gene Frequency Genetic Predisposition to Disease genetics Humans Incidence Kardiologi Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Mendelian randomization Middle Aged Original Research Polymorphism, Single Nucleotide Predictive Value of Tests Prognosis Protective Factors Risk Assessment Risk Factors Sex Factors Time Factors
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Zusammenfassung:	Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT. Baseline plasma adiponectin concentration was tested for association with baseline IMT, IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (β=-0.018, P
ISSN:	2047-9980 2047-9980
DOI:	10.1161/JAHA.115.001853