Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line
Highlights • Glucocorticoid (GC) dexamethasone down-regulates basal mRNA expression of the antimicrobial peptide genes CAMP (cathelicidin antimicrobial peptide), DEFB1 (human beta defensin 1), LZY (lysozyme) and SLPI (secretory leukocyte proteinase inhibitor 1) in THP-1 monocytes. • Dexamethasone re...
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| Veröffentlicht in: | Immunobiology (1979) 2016-02, Vol.221 (2), p.245-252 |
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| creator | Kulkarni, Nikhil Nitin Gunnarsson, Hörður Ingi Yi, Zhiqian Gudmundsdottir, Steinunn Sigurjonsson, Olafur E Agerberth, Birgitta Gudmundsson, Gudmundur H |
| description | Highlights • Glucocorticoid (GC) dexamethasone down-regulates basal mRNA expression of the antimicrobial peptide genes CAMP (cathelicidin antimicrobial peptide), DEFB1 (human beta defensin 1), LZY (lysozyme) and SLPI (secretory leukocyte proteinase inhibitor 1) in THP-1 monocytes. • Dexamethasone reduces vitamin D3 enhanced human cathelicidin ( CAMP ) gene expression in THP-1 monocytes, primary human monocytes and in the bronchial epithelial cell line BCi NS 1.1. • The Glucocorticoid receptor inhibitor RU486 prevents dexamethasone mediated inhibition of CAMP gene. |
| doi_str_mv | 10.1016/j.imbio.2015.09.001 |
| format | Article |
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agonists</subject><subject>Antimicrobial Cationic Peptides - antagonists & inhibitors</subject><subject>Antimicrobial Cationic Peptides - genetics</subject><subject>Antimicrobial Cationic Peptides - immunology</subject><subject>Antimicrobial polypeptides</subject><subject>beta-Defensins - antagonists & inhibitors</subject><subject>beta-Defensins - genetics</subject><subject>beta-Defensins - immunology</subject><subject>CAMP gene</subject><subject>Cell Differentiation</subject><subject>Cell Line</subject><subject>Chemokine CXCL10 - genetics</subject><subject>Chemokine CXCL10 - immunology</subject><subject>Cholecalciferol - antagonists & inhibitors</subject><subject>Cholecalciferol - pharmacology</subject><subject>Dexamethasone - pharmacology</subject><subject>Epithelial Cells - cytology</subject><subject>Epithelial Cells - drug effects</subject><subject>Epithelial Cells - immunology</subject><subject>Gene Expression Regulation</subject><subject>Glucocorticoid Receptor</subject><subject>Glucocorticoids - 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drug effects</subject><subject>Respiratory Mucosa - immunology</subject><subject>Signal Transduction</subject><issn>0171-2985</issn><issn>1878-3279</issn><issn>1878-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl9r1TAYh4so7jj9BILkC7Tmz2mTXijIplMYeKFeh_TNW0_O2qQk7bbzRfy8pjvbBEG8ykvye36BPCmK14xWjLLm7b5yY-dCxSmrK9pWlLInxYYpqUrBZfu02FAmWclbVZ8UL1La50DLpXpenPBG1Eo0zab4dTEsECDE2UFwlli8NSPOO5OCR2LDjS8j_lwGM2MinUlmIMZbcu1mMzpPzgVx3i6AloCZdzg4cDbv4-0UMSUXfD4nu2U0nozBBzisPWtDF4OHnct9OLk7Mo-Aw0AG5_Fl8aw3Q8JX9-tp8ePTx-9nn8vLrxdfzj5cltAINZe96jnabtsz4LQB3G6xR1A18F62Bti2s7atm14wZYQxsgcumwah5SgYqF6cFuWxN93gtHR6im408aCDcfp-6ypPqGtGZStzvv1nforB_oEeQCa4qqVkLLPiyEIMKUXsH2lG9WpU7_WdUb0a1bTVWVim3hypXDuifWQeFObAu2MA8ztdO4w6gUOflbiIMGsb3H8ueP8XD9mAAzNc4QHTPizRZwWa6cQ11d_WT7X-KVYLSmuuxG8_d87I</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Kulkarni, Nikhil Nitin</creator><creator>Gunnarsson, Hörður Ingi</creator><creator>Yi, Zhiqian</creator><creator>Gudmundsdottir, Steinunn</creator><creator>Sigurjonsson, Olafur E</creator><creator>Agerberth, Birgitta</creator><creator>Gudmundsson, Gudmundur H</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20160201</creationdate><title>Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line</title><author>Kulkarni, Nikhil Nitin ; Gunnarsson, Hörður Ingi ; Yi, Zhiqian ; Gudmundsdottir, Steinunn ; Sigurjonsson, Olafur E ; Agerberth, Birgitta ; Gudmundsson, Gudmundur H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c638t-f8f2edb4f1c206ce44efec85c2f79ac14bdd956f318a3aa7fc2766ec92e31c8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Advanced Basic Science</topic><topic>Allergy and Immunology</topic><topic>Anti-inflammatory</topic><topic>Antimicrobial Cationic Peptides - 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| identifier | ISSN: 0171-2985 |
| ispartof | Immunobiology (1979), 2016-02, Vol.221 (2), p.245-252 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Advanced Basic Science Allergy and Immunology Anti-inflammatory Antimicrobial Cationic Peptides - agonists Antimicrobial Cationic Peptides - antagonists & inhibitors Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - immunology Antimicrobial polypeptides beta-Defensins - antagonists & inhibitors beta-Defensins - genetics beta-Defensins - immunology CAMP gene Cell Differentiation Cell Line Chemokine CXCL10 - genetics Chemokine CXCL10 - immunology Cholecalciferol - antagonists & inhibitors Cholecalciferol - pharmacology Dexamethasone - pharmacology Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - immunology Gene Expression Regulation Glucocorticoid Receptor Glucocorticoids - pharmacology Humans Immunity, Innate - drug effects Interleukin-1beta - genetics Interleukin-1beta - immunology LL-37 Macrophages - cytology Macrophages - drug effects Macrophages - immunology Medicin och hälsovetenskap Mifepristone - pharmacology Monocytes - cytology Monocytes - drug effects Monocytes - immunology Muramidase - antagonists & inhibitors Muramidase - genetics Muramidase - immunology Poly I-C - pharmacology Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - immunology Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Respiratory Mucosa - immunology Signal Transduction |
| title | Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line |
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