Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line

Highlights • Glucocorticoid (GC) dexamethasone down-regulates basal mRNA expression of the antimicrobial peptide genes CAMP (cathelicidin antimicrobial peptide), DEFB1 (human beta defensin 1), LZY (lysozyme) and SLPI (secretory leukocyte proteinase inhibitor 1) in THP-1 monocytes. • Dexamethasone re...

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Veröffentlicht in:	Immunobiology (1979) 2016-02, Vol.221 (2), p.245-252
Hauptverfasser:	Kulkarni, Nikhil Nitin, Gunnarsson, Hörður Ingi, Yi, Zhiqian, Gudmundsdottir, Steinunn, Sigurjonsson, Olafur E, Agerberth, Birgitta, Gudmundsson, Gudmundur H
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Anti-inflammatory Antimicrobial Cationic Peptides - agonists Antimicrobial Cationic Peptides - antagonists & inhibitors Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - immunology Antimicrobial polypeptides beta-Defensins - antagonists & inhibitors beta-Defensins - genetics beta-Defensins - immunology CAMP gene Cell Differentiation Cell Line Chemokine CXCL10 - genetics Chemokine CXCL10 - immunology Cholecalciferol - antagonists & inhibitors Cholecalciferol - pharmacology Dexamethasone - pharmacology Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - immunology Gene Expression Regulation Glucocorticoid Receptor Glucocorticoids - pharmacology Humans Immunity, Innate - drug effects Interleukin-1beta - genetics Interleukin-1beta - immunology LL-37 Macrophages - cytology Macrophages - drug effects Macrophages - immunology Medicin och hälsovetenskap Mifepristone - pharmacology Monocytes - cytology Monocytes - drug effects Monocytes - immunology Muramidase - antagonists & inhibitors Muramidase - genetics Muramidase - immunology Poly I-C - pharmacology Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - immunology Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Respiratory Mucosa - immunology Signal Transduction
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Zusammenfassung:	Highlights • Glucocorticoid (GC) dexamethasone down-regulates basal mRNA expression of the antimicrobial peptide genes CAMP (cathelicidin antimicrobial peptide), DEFB1 (human beta defensin 1), LZY (lysozyme) and SLPI (secretory leukocyte proteinase inhibitor 1) in THP-1 monocytes. • Dexamethasone reduces vitamin D3 enhanced human cathelicidin ( CAMP ) gene expression in THP-1 monocytes, primary human monocytes and in the bronchial epithelial cell line BCi NS 1.1. • The Glucocorticoid receptor inhibitor RU486 prevents dexamethasone mediated inhibition of CAMP gene.
ISSN:	0171-2985 1878-3279 1878-3279
DOI:	10.1016/j.imbio.2015.09.001