Studies on human papillomavirus (HPV) 16 E2, E5 and E7 mRNA in HPV-positive tonsillar and base of tongue cancer in relation to clinical outcome and immunological parameters

Highlights • Most HPV 16 DNA positive TSCC and BOTSCC biopsies expressed HPV16 E7 mRNA. • Of HPV16 DNA E7 mRNA positive TSCC and BOTSCC, 65% also expressed E2 and E5 mRNA. • HPV16 DNA positive/E2 mRNA negative TSCC and BOTSCC had worse prognosis. • HPV16 E2, E5 and E7 mRNA expression was not correla...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oral oncology 2015-12, Vol.51 (12), p.1126-1131
Hauptverfasser:	Ramqvist, Torbjörn, Mints, Michael, Tertipis, Nikolaos, Näsman, Anders, Romanitan, Mircea, Dalianis, Tina
Format:	Artikel
Sprache:	eng
Schlagworte:	Base of tongue cancer Biomarkers Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - therapy CD8 Antigens - metabolism Disease-Free Survival Genes, MHC Class I Hematology, Oncology and Palliative Medicine HPV HPV E2, E5, E7 mRNA Human papillomavirus 16 - genetics Humans Lymphocytes, Tumor-Infiltrating - metabolism Medicin och hälsovetenskap Otolaryngology Papillomavirus Infections - genetics Papillomavirus Infections - therapy RNA, Messenger - genetics Survival Tongue Neoplasms - genetics Tongue Neoplasms - therapy Tonsillar cancer Tonsillar Neoplasms - genetics Tonsillar Neoplasms - therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Most HPV 16 DNA positive TSCC and BOTSCC biopsies expressed HPV16 E7 mRNA. • Of HPV16 DNA E7 mRNA positive TSCC and BOTSCC, 65% also expressed E2 and E5 mRNA. • HPV16 DNA positive/E2 mRNA negative TSCC and BOTSCC had worse prognosis. • HPV16 E2, E5 and E7 mRNA expression was not correlated to HLA class I expression. • HPV16 E2, E5 and E7 mRNA expression was not correlated to CD8+ TIL counts.
ISSN:	1368-8375 1879-0593 1879-0593
DOI:	10.1016/j.oraloncology.2015.09.007