The CCDC55 couples cannabinoid receptor CNR1 to a putative DISC1 schizophrenia pathway

Highlights • CCDC55 is expressed as a nuclear protein in human neuronal cells. • CCDC55 physically interacts with RanBP9 and DISC1. • CCDC55 and RanBP9 co-localize in the nucleus of human neuronal cells. • CCDC55 also interacts with the brain CNRIP1a and with CNR1. • CNR1 activation alters RanBP9 lo...

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Veröffentlicht in:	Neuroscience 2015-12, Vol.310, p.723-730
Hauptverfasser:	Xie, J, Gizatullin, R, Vukojevic, V, Leopardi, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism cannabinoid receptor 1 cannabinoid receptor interacting protein 1a Cell Line, Tumor coiled coil domain-containing 55 Cytoskeletal Proteins - metabolism disrupted-in-schizophrenia 1 HeLa Cells Humans Medicin och hälsovetenskap Nerve Tissue Proteins - metabolism Neurology Neurons - metabolism Nuclear Proteins - metabolism Ran binding protein 9 Receptor, Cannabinoid, CB1 - metabolism schizophrenia Schizophrenia - metabolism
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Zusammenfassung:	Highlights • CCDC55 is expressed as a nuclear protein in human neuronal cells. • CCDC55 physically interacts with RanBP9 and DISC1. • CCDC55 and RanBP9 co-localize in the nucleus of human neuronal cells. • CCDC55 also interacts with the brain CNRIP1a and with CNR1. • CNR1 activation alters RanBP9 localization in TPA-differentiated neuronal cells.
ISSN:	0306-4522 1873-7544 1873-7544
DOI:	10.1016/j.neuroscience.2015.10.012