Premature mortality in autism spectrum disorder

Mortality has been suggested to be increased in autism spectrum disorder (ASD). To examine both all-cause and cause-specific mortality in ASD, as well as investigate moderating role of gender and intellectual ability. Odds ratios (ORs) were calculated for a population-based cohort of ASD probands (n...

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Veröffentlicht in:British journal of psychiatry 2016-03, Vol.208 (3), p.232-238
Hauptverfasser: Hirvikoski, Tatja, Mittendorfer-Rutz, Ellenor, Boman, Marcus, Larsson, Henrik, Lichtenstein, Paul, Bölte, Sven
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Sprache:eng
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Zusammenfassung:Mortality has been suggested to be increased in autism spectrum disorder (ASD). To examine both all-cause and cause-specific mortality in ASD, as well as investigate moderating role of gender and intellectual ability. Odds ratios (ORs) were calculated for a population-based cohort of ASD probands (n = 27,122, diagnosed between 1987 and 2009) compared with gender-, age- and county of residence-matched controls (n = 2,672,185). During the observed period, 24,358 (0.91%) individuals in the general population died, whereas the corresponding figure for individuals with ASD was 706 (2.60%; OR = 2.56; 95% CI 2.38-2.76). Cause-specific analyses showed elevated mortality in ASD for almost all analysed diagnostic categories. Mortality and patterns for cause-specific mortality were partly moderated by gender and general intellectual ability. Premature mortality was markedly increased in ASD owing to a multitude of medical conditions.
ISSN:0007-1250
1472-1465
1472-1465
DOI:10.1192/bjp.bp.114.160192