A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell death. Since base excision repair (BER) activity is specifi...

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Veröffentlicht in:	BMC cancer 2015-12, Vol.15 (962), p.978-978, Article 978
Hauptverfasser:	Seibold, Petra, Schmezer, Peter, Behrens, Sabine, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Flesch-Janys, Dieter, Nevanlinna, Heli, Fagerholm, Rainer, Aittomäki, Kristiina, Blomqvist, Carl, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Lambrechts, Diether, Wildiers, Hans, Kristensen, Vessela, Alnæs, Grethe Grenaker, Nord, Silje, Borresen-Dale, Anne-Lise, Hooning, Maartje J, Hollestelle, Antoinette, Jager, Agnes, Seynaeve, Caroline, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Dunning, Alison M, Rhenius, Valerie, Shah, Mitul, Kabisch, Maria, Torres, Diana, Ulmer, Hans-Ulrich, Hamann, Ute, Schildkraut, Joellen M, Purrington, Kristen S, Couch, Fergus J, Hall, Per, Pharoah, Paul, Easton, Doug F, Schmidt, Marjanka K, Chang-Claude, Jenny, Popanda, Odilia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - mortality Cancer therapies Care and treatment Cell cycle Chemotherapy Chemotherapy, Adjuvant Complications and side effects Consortia DNA damage DNA repair Estrogens Exercise Female Genes Genetic aspects Genotype Genotype & phenotype Health aspects Humans Medical prognosis Middle Aged Poly(ADP-ribose) Polymerases - genetics Polymorphism, Single Nucleotide Postmenopausal women Postmenopause Prognosis Proportional Hazards Models Quality control Radiation therapy Radiotherapy Single nucleotide polymorphisms Tumors
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Zusammenfassung:	Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell death. Since base excision repair (BER) activity is specific for oxidative DNA damage, we hypothesized that germline genetic variation in this pathway will affect breast cancer-specific survival depending on treatment. We assessed in 1,408 postmenopausal breast cancer patients from the German MARIE study whether cancer specific survival after adjuvant chemotherapy, anthracycline chemotherapy, and radiotherapy is modulated by 127 Single Nucleotide Polymorphisms (SNPs) in 21 BER genes. For SNPs with interaction terms showing p
ISSN:	1471-2407 1471-2407
DOI:	10.1186/s12885-015-1957-7